di-4-anepps is a potentiometric fluorescent dye that can be used to measure membrane potential. it displays absorption/emission maxima of 495/705 nm, respectively. the relative fluorescence changes proportionally to membrane potential at a rate of approximately 10% per 100 mv. di-4-anepps has been used to measure membrane potential in a variety of tissue and cell types as well as artificial membranes.
DI-4-anepps is a membrane potential voltage-sensitive infectious material, which is widely used in biological and medical research due to its excellent properties. Its excellent temporal resolution of 1 ms and fluorescence change rate of up to 10% per 100 mV make it ideal for mapping cardiac electrical activity**.
In a rabbit ex vivo heart model, DI-4-Anepps showed a direct irreversible effect on spontaneous heart rate and ventricular impulse conduction. This means that DI-4-ANEPPS provides high-resolution and high-sensitivity monitoring of the electrical activity of the heart, both under physiological and pathological conditions.
However, the mechanism of action of DI-4-anepps still needs further research. Although its performance in cardiac electrobioactivity mapping is remarkable, it is unclear whether its direct irreversible effects on the heart have potential value or potential. Therefore, future research should focus on understanding the mechanism of action of DI-4-anepps and its specific applications in cardiac electrophysiology. In addition, the high fluorescence change rate of Di-4-Anepps has a broad application prospect in dynamic monitoring of cell membrane potential changes.
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This article is edited by Shaanxi Xinyan Bomei XYS.