Yu Juan, deputy chief physician of the Department of Rheumatology and Immunology of the First People's Hospital of Yunnan Province, said that as an autoimmune disease with an unclear pathogenesis, its manifestations are not only reflected in skin lesions, but also may affect the whole body system, but with the improvement of multidisciplinary awareness of the disease and the development of medicine, most patients can be effectively controlled after timely diagnosis and standardization, so as to obtain a better quality of life.
Yu Juan, Deputy Chief Physician of the Department of Rheumatology and Immunology, The First People's Hospital of Yunnan Province.
Visiting hours: All day on Tuesdays.
Experts are good at. He specializes in gout, systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis, ankylosing spondylitis, and Sjogren's syndrome.
Except for erythema. It may also have these manifestations.
According to Yu Juan, systemic lupus erythematosus is an autoimmune disease caused by multiple factors such as genetics, environment, and gender. The normal immune system will recognize itself and exclude others, while the immune function of systemic lupus erythematosus is disordered, attacking the dissidents at the same time, it will also attack its own normal cells, organs and tissues, and eventually lead to damage to various systems and organs throughout the body.
Lupus erythematosus was first used to describe the damage left by a wolf bite on the face, but Yu Juan said that not every patient will have this typical ** symptoms, some people will manifest as oral ulcers, joint pain, muscle pain, and optic neuropathy with eye involvement, fundus hemorrhage, and kidney damage, such as proteinuria, microscopic hematuria, abnormal renal function, and some patients also manifest as severe thrombocytopenia with blood system involvement. Hemolytic anemia can also affect our nervous system, digestive system, heart and lungs.
Some patients have intestinal obstruction, and they may go to surgery first, only to find out that it is actually a manifestation of gastrointestinal involvement caused by lupus erythematosusSome lupus encephalopathy presents with psychiatric symptoms, but these patients may be the first to go to a psychiatric department and eventually discover that they are also a ...... of systemic damage to lupusWith more attention to the disease, the improvement of disease methods, and the research progress of related drugs, patients have a better recovery, and the 20-year survival time has been greatly improved compared with ten years ago.
Women are more common.
There is a chance to have normal fertility under multidisciplinary escort.
The incidence of lupus erythematosus is generally 1:9 in men and women, and women of childbearing age are the most common group. So, is it still possible for them to have normal children?Will the disease be passed on to the next generation?
Yu Juan said that all diseases advocate early detection, early diagnosis, and lupus erythematosus has undergone a positive early stage, and the overall quality of life is very ideal, and it can even get married and have children like normal women, but the premise must be positive and standardized, regular follow-up and planned preparation for pregnancy. "For women with lupus erythematosus, pregnancy itself is a big trigger, and some women suddenly start to develop proteinuria, rash, low platelet ...... during their second pregnancyAs a result, lupus erythematosus was discovered, and it can be seen that the timing of pregnancy and the whole pregnancy need to be guided and evaluated by a doctor. If the mother has lupus erythematosus, her offspring will not necessarily have the disease, but if the mother has anti-SSA and/or anti-SSB antibodies, it is possible to pass these antibodies to the fetus through the placenta during pregnancy. This group of people needs to be managed in pregnancy under the strict coordinated monitoring of rheumatology and immunology, obstetrics and other disciplines. ”
At the same time, she also suggested that if there are women with systemic lupus erythematosus in their immediate family, they can go for an antinuclear antibody (ANA) screening, and if these abnormal antibodies are found in the body, some intervention can be done early. At the same time, some corresponding blood routine, urine routine, liver and kidney function and imaging examinations can also be carried out to determine whether there is early organ damage, and early detection of organ damage in the absence of clear obvious clinical symptoms.
These situations should be noted.
May cause condition**.
In patients with stable lupus erythematosus, when the immune system attacks foreign bodies, it may also mobilize its own immune system to attack normal organs and tissues indiscriminately, again leading to damage to the systemic system
Ultraviolet. UV exposure can increase lupus disease activity, Yunnan UV rays are strong, go out as much as possible to do a good job of sun protection.
Aesthetic Procedures. Female ** beautiful, but lupus erythematosus patients and high-risk groups should never do some prosthetic implantation projects, such as rhinoplasty, breast augmentation, etc. Others such as tattoos, hair coloring, and eyebrow tattoos are not recommended and may be some of the factors that predispose to the activity.
Individualization**.
Patients will benefit the most.
It is also a patient with lupus erythematosus, but each person's disease manifestations and severity and progression rate are different, so the doctor's ** plan can only be individualized.
Some patients only have ** mucous membranes or a manifestation of arthritis, and these conditions do not necessarily require the use of hormones, generally using drugs such as hydroxychloroquine and non-steroidal anti-inflammatory analgesics. For severe organ injury, including life-threatening thrombocytopenia, hemolytic anemia, severe lupus encephalopathy, and severe lupus nephritis, glucocorticoids are necessary for such patients. Yu Juan said that many people talk about hormone discoloration, and women will be more worried about becoming fat and changing their appearance after use, but choosing the right dose at the right time will indeed achieve a better effect. If this opportunity is missed, for example, the kidney damage has reached a chronic irreversible change, and the use of hormones will be half the effort. Doctors will definitely make individualized program selection from the patient's point of view, and strive to achieve the best disease control state with the smallest drugs.
Yu Juan said that patients with lupus erythematosus can be considered to reduce the dose of the drug to maintain the minimum dose or even finally stop the drug when they continue to reach a state of low disease activity or remission through continuous standardized ** evaluation. However, there are no clear studies to indicate which patients will become ill** after discontinuation, so follow-up after discontinuation is mandatory.