With the continuous advancement of fertility technology, more and more families choose to use the third generation of IVF technology to realize their fertility dreams. However, many people are concerned about whether autoantibodies will have an impact on third-generation test tubes. This topic has become a hot topic that has attracted much attention. So, do autoantibodies have an effect on third-generation test tubes?What's going on?Based on this, let's take a look at what the specific situation looks like.
After more than 30 years of research, it has been found that there are many factors influencing the success rate of IVF, and the positive autoantibody may not only be related to infertility and sexual abortion, but also affect the success rate of IVF.
Positive for a single autoimmune antibody
1. The effect of positive anti-sperm antibodies on IVF
Some studies have reported that the sperm-egg binding rate of ASAB-positive patients in female serum is significantly affected, while there is no significant difference in egg maturity and the proportion of high-scoring embryos.
However, other studies suggest that ASAB levels in sperm, serum, and follicular fluid may not be related to IVF pregnancy outcomes. There was no significant difference in pregnancy rates between the ASAB-positive and negative groups in sperm Y.
2. The effect of positive anti-ovarian antibodies on IVF
The positivity rate of AOAB in infertile women is as high as 367%～59.In 7%, it has been reported that the pregnancy rate of AOAB-positive patients in patients who received IVF** for the first time was 1053%, significantly lower than the 3172%, speculating that anti-ovarian antibodies may affect the process of sperm-egg binding and egg**, thus affecting the outcome of IVF.
3. The effect of positive anti-endometrial antibody on IVF
It is speculated that EMAB binds to endometrial tissue, resulting in endometrial dysfunction, which mainly affects embryo implantation in IVF.
In the analysis of the pregnancy outcomes of IVF** in women with unexplained infertility, there was no significant difference in the biochemical pregnancy rate between the EMAB-positive group and the negative control group, the miscarriage rate of the antibody-positive group was significantly higher, and the ongoing pregnancy rate was lower than that of the negative control group.
4. The effect of positive anticardiolipin antibody on IVF
Positive anticardiolipin antibody significantly affects the outcome of IVF, resulting in uterine microvascular thrombosis, changes in the function of embryonic trophoblast cells, affecting embryo implantation, placental formation and early embryonic development, and causing infertility, early miscarriage or repeated implantation failure of IVF.
The sperm-egg binding rate, pregnancy rate, and embryo implantation rate of IVF in patients with positive anticardiolipin antibody were significantly lower than those in the antibody-negative group, and the miscarriage rate was significantly higher, so anticardiolipin antibody had a negative effect on the outcome of IVF.
Effect of multiple autoantibody positivity on IVF
A study analyzed the effect of three kinds of autoimmune antibodies (anticardiolipin antibody, anti-ovarian antibody and anti-sperm antibody) on the outcome of IVF, and found that the more types of positive antibodies, the lower the pregnancy rate, and the three antibodies may act on embryo implantation and early development after implantation through different mechanisms, jointly reducing the success rate of IVF.
In one study, four autoimmune antibodies (anticardiolipin antibody, anti-thyroid antibody, HCG antibody and anti-endometrial antibody) were analyzed on IVF outcomes.
Tips:
Autoantibodies may have an impact on the success rate of third-generation IVF, but there is insufficient research evidence. If you are considering a third-generation IVF, it is important to consult a professional and undergo a thorough examination and evaluation. In addition, increasing exercise and maintaining a healthy lifestyle are also important factors in increasing the success rate.