Psoriasis, commonly known as "psoriasis", will make patients have a rash or plaque, covered with silvery-white scales, causing itching and tingling, and some patients will also have arthritis, pustules and other manifestations.
Intense itching, visible changes and possible inconvenience often make it difficult for patients to work and live, and suffer both physical and psychological torture. Therefore, both the patient and the patient's family are eager to find a way to do it.
So can psoriasis be completely **?Let's talk about it today.
Psoriasis can't**, but it can be well controlledPsoriasis is an immune-related chronic, **, inflammatory, systemic disease, and its causes are extremely complex. In addition to genetic factors, environmental factors such as seasonal climate, humidity, trauma, alcohol consumption, and mental stress can also induce psoriasis, so far the medical community has not found a cure for psoriasis.
Here I would like to remind you again, don't believe in advertisements such as "once, never, thoroughly", many home remedies contain hormones and other ingredients, which may get better in the short term, but as soon as the medicine is stopped, it will explode into red skin.
There are also some home remedies containing toxic substances such as mercury, which are not only not good for the condition, but also cause liver and kidney damage to the liver and kidney function after long-term use, but make the condition more and more serious.
It is gratifying that although psoriasis cannot be **, through reasonable and standardized medication, most patients' conditions can be reduced, and skin lesions will regress, and they can reach several years or even decades. 2There are many traditional diseases, and the disease cannot be controlled for a long timeFor a long time, the domestic treatment of psoriasis is mainly based on traditional systemic methods, including hormone topical drugs, light and systemic drugs, and the combination of these conventional methods can make 80% of patients achieve very satisfactory results.
However, unfortunately, many patients have not been able to achieve long-term standardized medication, which makes the best effect unsatisfactory. Some patients are because the traditional ** method needs to be used more than three times to be effective, because the response is too slow, and many people can't stick to it after using it.
Some patients are because there are more restrictions on traditional **, such as people of childbearing age who cannot take some medicines, and they can only get pregnant after two years of stopping the drugs.
There are also some patients because some oral drugs will bring high blood pressure, hyperlipidemia, damage to the liver, etc.
A survey of psoriasis patients showed that 62% of patients said they were dissatisfied with the current regimen, 67% of patients had adverse reactions, and 82% of respondents said they had self-medicated.
Biologics become a new hope for psoriasis patientsThe advent of biologics has led to a transformative breakthrough in psoriasis**, which works by mimicking or interfering with the function of a cytokine in the body. Compared with the traditional system approach, biologics have the characteristics of safety, high efficiency, fast onset of action, and high complete removal rate of skin lesions, which can improve psoriasis skin lesions by 90% or even 100%.
The most important thing is that the biologics are very small and basically do not affect liver and kidney function.
So when is it better to use biologics?
In the past, biologics were often recommended as second-line regimens after failed psoriasis such as methotrexate, cyclosporine, or phototherapy. In recent years, with the accumulation of clinical evidence, the status of biologics in psoriasis has also increased.
The 2017 edition of the British Society of Diseases (BAD) Guidelines for Biologics for Psoriasis points out that for patients with psoriasis whose disease severity meets the criteria, or patients with psoriatic arthritis, and patients with long-term moderate to severe psoriasis, the timing of biologics selection can be appropriately advanced.
At present, there are three main types of biologics commonly used in clinical practice:
Tumor necrosis factor- (TNF-) inhibitors: Representative drugs are etanercept, infliximab, adalimumab, golimumab, and certolizumab.
IL-12 IL-23 inhibitors: representative drugs include ustekinumab and gusekumab.
IL-17 inhibitors: representative drugs include secukinumab and ixekizumab. IL-12 IL-23 inhibitors and IL-17 inhibitors have significant advantages over tumor necrosis factor- (TNF-) inhibitors in moderate-to-severe psoriasis.
Take IL-17 inhibitors, for example. Data from a phase III study in China showed that nearly ninety percent of all patients with moderate-to-severe psoriasis who received secukinumab 300 mg** achieved skin lesion clearance or nearly clearance at week 16, which is better than in other countries.