1. Product introduction.
Sodium tert-butanol, with the chemical formula C4H9ONA, is an organic compound with strong irritation. It is a white or light yellow crystal, soluble in water, soluble in organic solvents such as methanol and ethanol. Sodium tert-butoxide is an important intermediate in organic synthesis, which is widely used in medicine, pesticides, liquid crystal materials and other fields.
2. Synthesis method.
There are two main synthesis methods of sodium tert-butanol: one is the reaction of tert-butanol with sodium hydroxide, and the other is the reaction of isobutylene with sodium hydroxide. Here's a closer look at the two methods:
Method 1: Reaction of tert-butanol with sodium hydroxide.
1.Mix tert-butanol and sodium hydroxide in a ratio of 1:1 to the amount of the substance.
2.Heat the mixture to 80-100 °C and stir until the reaction is complete.
3.The reaction solution was acidified with dilute hydrochloric acid to convert sodium tert-butanol into tert-butanol, which was convenient for subsequent separation.
4.The upper organic phase was separated by a separating funnel and dried with anhydrous sodium sulfate.
5.Distill, collect 100-120 13kpa fraction to obtain pure sodium tert-butanol.
Method 2: Isobutylene reacts with sodium hydroxide.
1.Isobutylene and sodium hydroxide are mixed in a ratio of 2:1 to the amount of the substance.
2.Heat the mixture to 60-80 and stir until the reaction is complete.
3.The reaction solution was acidified with dilute hydrochloric acid to convert sodium tert-butanol into tert-butanol, which was convenient for subsequent separation.
4.The upper organic phase was separated by a separating funnel and dried with anhydrous sodium sulfate.
5.Distill, collect 100-120 13kpa fraction to obtain pure sodium tert-butanol.
Third, the field of application.
1.Pharmaceutical field: sodium tert-butoxide can be used to synthesize a variety of antibiotics and drugs, such as cephalosporins, penicillins, etc. It is also an important intermediate in the synthesis of anticancer drugs and ** drugs for cardiovascular diseases.
2.Pesticide field: sodium tert-butoxide can be used to synthesize a variety of pesticides, such as herbicides, insecticides, etc. It is also an important intermediate in the synthesis of plant growth regulators.
3.Liquid crystal materials: sodium tert-butoxide can be used to synthesize a variety of liquid crystal materials, such as twisted nematic liquid crystals, near-crystalline liquid crystals, etc. These liquid crystal materials have a wide range of applications in display technology, optical devices and other fields.
4.Other fields: sodium tert-butanate can also be used in the synthesis of organic compounds such as surfactants and chelating agents. In addition, it can also play a role in chemical production as a catalyst and solvent.
4. Precautions.
1.Sodium tert-butoxide is a strong irritant, and protective glasses and gloves need to be worn during operation to avoid direct contact** and inhalation of its dust.
2.In the synthesis process, it is necessary to control the reaction temperature and stirring rate to avoid safety accidents caused by violent reactions.
3.Sodium tert-butoxide is easily deliquescent and should be stored in a dry, cool place to avoid contact with water. At the same time, it is necessary to prevent it from oxidation and pollution to ensure product quality.