Some people will ask why there are no protective antibodies against hepatitis B after three doses of hepatitis B vaccineThis is the case and accounts for 5% to 10% of the hepatitis B vaccine population. So, how can you promote the production of protective antibodies against hepatitis B?
First, you can get the hepatitis B vaccine again. One (1) dose of 60 ug or three (3) doses of 20 μg of hepatitis B vaccine should be given and serum anti-HBS should be tested 1 2 months after the completion of the second dose, and if it still fails, a further dose of 60 ug of recombinant yeast hepatitis B vaccine can be given.
Secondly, it is necessary to pay attention to whether there are immunodeficiency or immune dysfunction caused by the following diseases: HIV infection, HCV infection, end-stage renal disease or dialysis, diabetes, obesity, inflammatory bowel disease, etc. These disorders can cause patients to have a low or no response to the hepatitis B vaccine;
For those who cannot produce protective antibodies against hepatitis B after repeated or increased doses of hepatitis B vaccine, the following measures can be tried: change the vaccination route (intramuscular injection to intradermal injection), use of immune adjuvants (δinulin, CPG oligonucleotides, immunostimulatory DN** segment), improve immunogenicity (pre-S1 and pre-S2 viral particles), use immune co-stimulators (such as levamisole, praziquantel, cimetidine, etc.).
Further consultation with a medical professional or outpatient clinic can be used for specific conditions.