The reason for the change of phosphatidylserine in water is mainly related to its molecular structure and amphoteric properties.
The molecular structure of phosphatidylserine contains a hydrophilic phosphoinositide head and a hydrophobic fatty acid tail, which makes phosphatidylserine have the characteristics of amphoteric molecules, that is, it is both hydrophilic and hydrophobic, and this amphoteric structure causes the molecule to self-assemble in water to form tiny colloidal particles with lipid bilayer structure.
Phosphatidylserine molecules tend to self-assemble in water to form lipid bilayers to minimize the interaction between water and hydrophobic tails, and this self-assembly ability enables phosphatidylserine to form tiny colloidal particles in water that are hydrophilic on the surface and hydrophobic on the inside.
The tiny colloidal particles of phosphatidylserine have a certain stability in water, because the hydrophilic head interacts with the water molecules, and the hydrophobic tail repels the water molecules, so that the colloidal particles can maintain a certain structure and stability in the water.
The behavior of phosphatidylserine in water is also affected by environmental conditions, including temperature, ion concentration, pH, etc. These factors may affect the amphoteric properties of the molecule, which in turn affects the degree of self-assembly and the formation of colloidal particles.
The reason for the change of phosphatidylserine in water is mainly due to the self-assembly behavior caused by its amphoteric molecular structure, forming tiny colloidal particles, which is of great significance for simulating cell membrane structure and preparing drug carriers.