Y-type PEG acetaldehyde is an N-terminal reactive Y-type 2-arm PEG. Y-type PEGs are more selective than linear PEGs due to their large spatial structure. The polyethylene glycol arm has hydrophilicity and other excellent physical and chemical properties. For example, PEG chains can inhibit the non-specific binding of charged molecules to modified surfaces. The aldehyde group (ALD) exhibits several interesting reactions (with amines, hydrazine, etc.). Compared to Y-shaped propionaldehyde, Y-shaped PEG acetaldehyde is more selective but less reactive. In the presence of a reducing agent, it reacts with an N-terminal amine (e.g., the N-terminus of GSF, RHGCSF) at pH 5-8. Y-type PEG acetaldehyde is an N-terminal reactive Y-type 2-arm PEG that is more selective than linear PEG in linking proteins and peptides due to its large spatial structure. The polyethylene glycol arm has hydrophilicity and other excellent physical and chemical properties, such as the PEG chain, which inhibits the non-specific binding of charged molecules to the modified surface.
The aldehyde group is a very important functional group of Y-type PEG acetaldehyde, which exhibits several interesting reactions that can react with amines, hydrazine, etc. Compared to Y-shaped propionaldehyde, Y-shaped PEG acetaldehyde is more selective but less reactive. In the presence of a reducing agent, it reacts with an N-terminal amine (e.g., the N-terminus of GSF, RHGCSF) at pH 5-8.
Appearance: Powder.
Storage conditions: Protect from light, dry, -20 storage.
Precautions: Be sure to dry when taking and avoid frequent dissolution and freeze-drying.
Tips: This reagent is only used for scientific research or industrial applications, and is not medicinal or edible.
In addition to being reactive, Y-type PEG acetaldehyde has good water solubility and low toxicity and immunogenicity. It can be used to prepare protein drugs, peptide drugs and gene drugs to improve the stability and targeting of drugs.
The above is the relevant content shared by XYS, the editor of Xinyan Bomei.