Many patients may have had the experience that in addition to the diagnosis results, the pathology report they receive will also show "immunohistochemistry results: xx, xx..."Such content, or receive a delay notice of pathology report, because "immunohistochemistry" is needed for further diagnosis or auxiliary diagnosis.
What is this "immunohistochemistry"?
The full name of immunohistochemistry is "immunohistochemistry technology", as a technology commonly used in pathological diagnosis, the application in clinical diagnosis mainly has the following aspects: the judgment of benign and malignant tumors due to the difference between reactive hyperplasia and neoplastic in the clonality of B lymphocyte proliferation, reactive hyperplasia is polyclonal, neoplastic is monoclonal, can be detected by the light chain antibody of immunoglobulin.
An indicator to determine the tumor stage and prognosis can be determined by immunohistochemistry to determine whether the tumor is infiltrating, whether there is lymphatic vessels or vascular invasion. The determination of cell properties determines the attributes of cells and determines the ** of tumors by marking the corresponding antigen components in the cell with specific antibodies.
Through in-depth study of these antigens, it is also possible to determine the primary site of unidentified metastases.
As an emerging method, markers and drug targets can determine the target of the drug, evaluate the efficacy of the drug, and the response of the drug, which requires the quality control of pathological diagnosis to be raised to a higher level.
Other IHCs can also classify "undifferentiated" malignancies, further classify tumors at the junction of different organs and tissues, diagnose infectious diseases, etc.
Three roles of immunohistochemistry in pathology.
Helps in diagnosis, mainly in the diagnosis of tumors. Helps confirm the tissue of tumor cells** and identifies the primary site of the tumor.
Distinguish benign and malignant tumors and judge the prognosis of patients.
Guidance on clinical medication. Correct results of immunohistochemistry depend on correct interpretation and should not be interpreted in isolation when reporting immunohistochemical staining results, taking into account the diagnostic and differential diagnosis, the characteristics of the antibody applied, the nature of the tissue studied, and the interference of false positive and false negative results. Only by striving for excellence in all aspects can we truly be responsible for every patient. Autumn and Winter Check-in Challenge