In 2023, with the help of the one-stop TCM research system solution of Zhongke New Life, we have published articles from many partners in journals such as Journal of Ethnopharmacology, PhytoMedicine, BioMed Pharmacother, Pharmacol Res, Clinical and Translational Medicine, etc. Today will be released in the direction of traditional Chinese medicinePhase 1Highlights, the follow-up is more exciting content, please pay attention!
Medicinal plants and authenticity research
The authenticity of traditional Chinese medicine is an important part of the medicinal properties of traditional Chinese medicine, and it is the exclusive characteristic of traditional Chinese medicine, which adheres to the changes of heredity and the similarities and differences of the environment, embodies the "sex-efficacy" relationship, and is the drug attribute that produces differences in clinical efficacy. Its research contents include the genetic causes of authenticity of traditional Chinese medicine, the environmental causes of authenticity of traditional Chinese medicine, the material basis of authenticity of traditional Chinese medicine, and the study of the "sex-efficacy" relationship of authenticity of traditional Chinese medicine.
In addition to traditional Chinese medicine fingerprint characterization,Analysis of components of traditional Chinese medicinesIt can analyze the composition and changes of TCM chemicals in different origins and parts of the country in a more detailed manner, and then discover more accurate quality markers. In addition, the analysis technology of spatial component group, which can more finely identify the distribution characteristics of drug components in the tissue space of medicinal materials, has also begun to be gradually applied to the study of the authenticity of traditional Chinese medicine.
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Document Name:chemical constituents, antioxidant, and α-glucosidase inhibitory activities of different fermented gynostemma pentaphyllum le**es and untargeted metabolomic measurement of the metabolite variation
Published in Journals:antioxidants
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Collaborators:Southwest Forestry University.
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Document Name:characterization of metabolite landscape distinguishes wild from cultivated polygonati rhizomes by uhplc-q-tof-ms untargeted metabolomics
Published in Journals:food bioscience
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Collaborators:The Hong Kong University of Science and Technology.
Gut microbiota studies
The intestinal flora is not only in line with the theory of traditional Chinese medicine, but also one of the main ways for traditional Chinese medicine to exert its efficacy. Through the analysis of the intestinal microbiome, although the effect of traditional Chinese medicine on the composition of intestinal microbiota can be described, it cannot fully analyze how the intestinal microbiota is further affected by the regulation of drugs. Therefore, the integration of gut microbiome and multi-omics analysis of target organs can completely connect the process of intestinal microbiota-microbiota active substance-target organ function improvement, so as to comprehensively analyze the complete regulatory mechanism of TCM on pathology through intestinal microbiota, and help further discover key functional microbiota.
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Document Name:patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of alzheimer's disease via modulating neuropathology and gut microbiota through suppressing c/ebpβ/aep pathway
Published in Journals:j neuroinflammation
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Collaborators:Chinese University of Hong Kong.
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Document Name:multi-omics reveals dengzhan shengmai formulation ameliorates cognitive impairments in d-galactose-induced aging mouse model by regulating cxcl12/cxcr4 and gut microbiota
Published in Journals:front pharmacol
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Collaborators:Institute of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences.
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Document Name:prophylactic effect of tongxieyaofang polysaccharide on depressive beh**ior in adolescent male mice with chronic unpredictable stress through the microbiome-gut-brain axis
Published in Journals:biomed pharmacother
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Collaborators:Tongren Vocational and Technical College, Sichuan Agricultural University.
Single-herb research
Omics technology can detect the molecular profile changes and interactions of the body under the action of physiology, pathology and drugs in multiple dimensions and with high throughput. In addition to the widely used proteomics, metabolomics and other technologies, single-cell omics and spatial omics have gradually become powerful tools for the study of traditional Chinese medicine, which provides further possibilities for revealing the mechanism of action of traditional Chinese medicine diseases, and also provides new ideas for the modernization of traditional Chinese medicine.
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Document Name:the involvement of th1 cell differentiation in the anti-tumor effect of purified polysaccharide from sanghuangporus vaninii in colorectal cancer via multi-omics analysis
Published in Journals:int j biol macromol
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Collaborators:Jilin University Jilin Agricultural University.
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Document Name:understanding aconite's anti-fibrotic effects in cardiac fibrosis
Published in Journals:phytomedicine
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Collaborators:Chengdu University of Traditional Chinese Medicine.
Benefits at the end of the article
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Recommended by Zhongke Youpin
With nearly 20 years of experience in mass spectrometry analysis and multi-omics research services, aptbio has established an exclusive chemical composition analysis platform and multi-omics research and analysis platform for traditional Chinese medicine. Since the launch of TCM-related technical services, aptBIO has completed the analysis and testing of the composition of more than 100 TCM compounds, covering a variety of dosage forms of more than 400 TCM compounds (extracts, powders, powders, tablets, ointments, pills, patches, lyophilized powders, capsules, formula granules, injections, etc.), as well as different types of drug-containing organisms (blood, milk, intestinal fluid, etc.), and drug-containing biological tissue samples (heart, liver, kidney, brain, intestines, pancreas, etc.). We organically integrate component analysis and multi-omics analysis to provide three major solutions for TCM research:TCM pharmacodynamic mechanism and active substance discovery solutions, active monomer mechanism and drug target identification solutions, quality and process research solutionsThe results of the service project have been published in: Acta Pharmaceutica Sinica B, Phytomedicine, Chinese Medicine, Biomedicine & Pharmacotherapy, Journal of Ethnopharmacology and other academic journals, as well as used in the secondary development of large varieties of Chinese medicine, the development of Chinese medicine prescriptions, the development of hospital preparations, the development of Chinese medicine health products, Development of innovative drugs of traditional Chinese medicine, development of traditional Chinese veterinary drugs, etc.
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