Introduction to the SDC2 gene
SDC2 (cohesin proteopolysaccharide 2) is a membrane protein involved in cell proliferation, cell migration, and interaction with extracellular matrix proteins, and its methylation has been shown to be closely related to the occurrence of colorectal cancer.
Relationship between SDC2 and tumorigenesis
There are broad differences in DNA methylation patterns between normal and cancer cells, for example, it has been reported that the methylation levels of target regions in colorectal cancer tissues are significantly higher than those in SDC2 target regions in adjacent non-colorectal cancer tissues. Abnormal hypermethylation of DNA is related to the occurrence and development of cancer, and some studies have analyzed the methylation of cancer tissues and adjacent tissues of colorectal cancer patients, and screened out the methylated SDC2 gene with significant differences. In the study of SDC2 gene methylation in stool samples, it was found that the specificity was 90At 9%, the detection sensitivity of colorectal cancer is 900%。Compared with normal tissues, the SDC2 gene exhibits a high level of methylation in colorectal cancer and adenoma tissues, and the expression of SDC2 gene in colorectal cancer and adenoma tissues is also significantly higher than that in normal tissues[3]. SDC2 gene is highly methylated in different stages of colorectal cancer, which indicates that it has high value as a diagnostic marker for colorectal cancer. Approved products for SDC2 methylation testing (or products entering clinical trials).
1) Human SDC2, NPY, FGF5, PDX1 Gene Methylation Detection Kit (Fluorescent PCR Method) (CSZ2100041).
2) SEPTIN9 SDC2 BCAT1 Gene Methylation Assay Kit (PCR-fluorescent probe method) (CSZ2000117).
3) Human SFRP2 and SDC2 Gene Methylation Combined Detection Kit (Fluorescent PCR Method) (CSZ2100018).
4) SDC2 and TFPI2 Gene Methylation Combined Detection Kit (Fluorescent PCR Method) (CSZ2100044).
5) Human SDC2 Gene Methylation Detection Kit (Fluorescent PCR Method) (CSZ1800035).
With the increasing maturity of genomic DNA methylation detection methods, methylation detection has become an important means of molecular diagnosis of related tumors and genetic diseases. To date, there is no complete standard for DNA methylation testing. The DNA methylation standard customized by Starfish Biotech has excellent repeatability and stability, which fills the gap of lack of methylation standards in China.
Starfish Biomethylated GDNA Reference** is based on its own cell bank, HYCYTE M series cells, which have the characteristics of both clinical specimens and tumor cells, with high quality stability, good uniformity, sustainable provision, stable batch, traceability, and no ethical risk. According to the needs of different detection platforms, different technologies such as BSP, pyrosequencing, QMSP, digital PCR, NGS and other technologies can be used for value determination, and the reference material without methylation gradient can be formulated to meet the needs of early research and development. Provide production records and testing documents to meet the needs of raw materials for kit production.
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