Liposome is a new type of pharmaceutical preparation with targeted drug delivery function, which is a preparation formed by encapsulating drug molecules by using vesicles formed by phospholipid bimolecular membranes, which has both hydrophilic and hydrophobic properties. Lipid nanoparticles (LNPs) are a type of nanoparticle formation using lipids. Liposomes are widely studied nanodrug carriers in drug delivery systems, and liposomes have a biofilm-like structure that can encapsulate water-soluble and fat-soluble drugs. It has the characteristics of high selectivity, no toxicity, no immunogenicity, and suitable for degradation in vivo. As a drug carrier, liposomes have a high degree of targeting, can effectively protect the encapsulated drug and control the release of sustained-release drugs, improve the drug ** index, and reduce the adverse reactions of drugs.
Liposomes can encapsulate different chemical drugs, nucleic acids, fluorescents, sonsenitizers, photosensitizers, etc. The surface of the liposome can be modified with different targeting peptides, including GE11 targeting peptide, PTP pancreatic cancer targeting peptide, RVG29 brain targeting peptide, SP94 liver cancer targeting peptide, RGD line peptide, CRGD cyclic peptide, IRGD cyclic peptide, etc., and different serial number targeting peptides can also be customized according to requirements. In addition to targeting peptides, liposomes can also modify different antibodies, fluorescence, aptamers, etc.
Eight nanomaterial drug delivery platforms.
1.Polymer micelles capsule drug delivery platform.
2.Liposomal drug delivery platform.
3.Magnetic lipid nanoparticle drug delivery platform.
4.Polymer (protein, dendritic macromolecule) nanoparticle drug delivery platform.
5.Nano emulsion drug delivery platform.
6.Gold nanoparticles (spherical particles, gold nanorods) drug delivery platform.
7.Nano graphene drug delivery platform.
8.Intelligent gel drug delivery platform.