NanoemulsionWith potential advantages such as smaller droplet size and better stability compared to traditional emulsions, their applications in the food, cosmetics and pharmaceutical industries are gaining traction. Nanoemulsions contain a very large number of small droplets, and their ability to scatter light waves is very weak, so they can be used to make optically clear products. The bioavailability of bioactive substances can be improved by coating bioactive substances and designing nanoemulsions.
Essential oils are oily substances extracted from aromatic plants with oil gland cells and are a class of natural fragrances. The chemical properties are extremely unstable, and there are problems such as volatile and oxidation during use, and the single liquid form also limits its application range. Embedding essential oils can not only improve the stability of essential oils but also extend their shelf lifeIt can also be used in other states, such as powdering essential oils in liquid form, to broaden the range of use.
Enhances the penetration of active ingredients.
Oil-in-water nanoemulsions are more suitable for transporting lipophilic compounds than liposomes due to their internal lipophilicity. And similar to liposomes, these lipophilic components support the penetration of the active ingredient on **, thereby increasing the concentration of the active ingredient in **. In addition, due to the small particle size and larger specific surface area of the nanoemulsion droplets, it is conducive to the transdermal absorption of the active substances in the inner phase, reducing the use of permeation enhancers and eliminating the irritation that may be brought by the permeation enhancers, thus helping to play the role of functional ingredients safely and quickly.
Improve the stability and utilization of the active ingredient.
This technology allows for the addition of unstable, highly active components that are difficult to incorporate in traditional emulsions to formulations. The nanoemulsion coats the lipophilic active component in the nanodroplet, which can reduce the contact between the active component and oxygen, thereby improving the stability and efficiency of the active ingredient. When the transdermal absorption of the active ingredient is improved, the content of the active ingredient that can be used by the human body is also increased, thereby increasing the utilization rate of the active ingredient.
Enhance usability.
Compared with traditional emulsions, nano emulsions can overcome the flocculation and agglomeration and sedimentation caused by gravity and Brownian motion during storage due to their small droplet size, and the stability of the product's shelf life can be guaranteed to a certain extent. Nano emulsion has a transparent appearance, uniform texture, and a good skin feel when used, which will improve the consumer's consumption experience. In addition, the properties of the nanoemulsion itself may reduce transepidermal water loss and enhance the barrier function.
Control release and targeting.
As a new type of transcutaneous delivery system, nanoemulsion has the functions of passive targeting and sustained-release controlled-release, and compared with other targeted drug delivery systems such as liposomes, nanoemulsion has smaller particle size, more delicate system, more stable physical and chemical properties, and better skin feel.
First of all, the wall material is equipped with a saturated aqueous solution, and then essential oils and emulsifiers are addedHomogeneous emulsificationFinally, the liquid mixture, through a series of pore membranes, is squeezed into a dehydrated solvent (usually isopropanol). When the emulsion extruded by the pore film comes into contact with the dehydrated solvent, the wall material will also be dehydrated and hardened, and the surface of the core material will be coated. After filtration, the microcapsule crude product is separated from the dehydrated solvent isopropanol, and the glassy embedding product can be obtainedDry grinding can also be continued to obtain a powdered embedding product.
Microfluidic homogenizer mini model.
Cooling water circulator.
PSS nanoparticle size analyzer.
Homogeneous and dispersed, the particle size distribution PDI < 02
Experimental phenomenon. The untreated sample is not permeable, has blistering, and has poor flowability.
Particle size detection. After homogenization and dispersion by the microfluidic homogenizer of Nozars Fluids, the average particle size of the sample was 1128nm with a PDI value of 006. To meet the needs of customers.