Application of talcum powder in the formulation process

Mondo Health Updated on 2024-01-28

(1) Used as a dispersant for volatile oils.

Because talcum powder has a certain adsorption capacity, it can adsorb volatile oil to the surface of its particles and disperse it evenly, and increase the solubility of volatile oil by increasing the contact area between volatile oil and liquid medicine.

2) Wrap the powder coating.

In sugar coating, talcum powder can be used for powder coating, white talcum powder through 100 mesh sieve is appropriate, the dosage is generally 3% 6%, which can not only eliminate the edges and corners to facilitate the coating, but also improve the stability of the sugar-coated tablets. When transitioning from the powder coating to the sugar coating layer, pay attention to the amount of talc and syrup, and the amount of talc gradually decreases.

3) Used as a lubricant.

At present, talcum powder is often used as a lubricant in the prescription of dispersible tablets, capsules, chewable tablets, effervescent tablets, and sustained-release tablets. Talcum powder can reduce the friction between drug powders and improve the fluidity of drug powders by filling the depressions on the surface of drug powders. When talcum powder is used as a lubricant, the dosage is generally 01% 3%, no more than 5%.

4) Used as a filter aid.

Talcum powder is not easy to react with drugs and has a certain adsorption capacity, so it can be used as a filter aid. After 115 activation, talcum powder, when added to the liquid medicine while hot, can adsorb a small amount of polysaccharides, mucus, gum impurities, and almost will not destroy the active ingredients of the drug itself. It should be noted that talcum powder is very fine and not easy to filter.

Related Pages