Dota-NHS ester, whose full name is 1,4,7,10-tetraazacyclopentadecane-1,4,7,10-tetraacetic acid, is a commonly used polydentate ligand and is widely used in the biomedical field. As a highly effective chelating agent, DOTA-NHS Ester is able to bind to transition metal ions to form stable chelates for labeling and imaging of radionuclides and metal ions.
Product name: Tetraazacyclododecanetetraacetic acid-N-hydroxysuccinimide.
Product Name: dota-nhs ester
Chinese chemical name: 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid 1-(2,5-dioxo-1-pyrrolidin) ester.
cas：170908-81-3
MF: C20H31N5O10
Structural Formula:
In biomedical research, DOTA-NHS ester is often used in the preparation of radiopharmaceuticals and fluorescent labels. By binding to a target molecule such as a protein, antibody, or small molecule, DOTA-NHS Ester improves the stability of the target molecule and increases its residence time in vivo.
In addition, DOTA-NHS ester can also be used to prepare nanomaterials and drug carriers. By binding to nanomaterials or drug molecules, DOTA-NHS Ester is able to improve the solubility and targeting of drugs.
In conclusion, DOTA-NHS ester, as an important polydentate ligand, has a wide range of applications in the biomedical field. With the continuous deepening of research and the development of technology, dota-nhs ester will play an even more important role in the medical and scientific fields in the future.