Everyone knows the Nobel Prize, and winning the Nobel Prize means that the research in a certain field is quite remarkable!So what does the Nobel Prize have to do with tadalafil and sildenafil today?There is really !!
It can be said that if there was no Nobel Prize, there would be no Viagra later, and there would be no sildenafil and tadalafil now.
It is said that the Nobel Prize is actually a scientist named Nobel. The Nobel Prize is an award that Sweden created in the name of Nobel after Nobel's death. Nobel is known as the king of explosives, because he invented the famous glycerin explosives.
Glycerin explosives, to put it bluntly, are explosives with nitroglycerin as the main raw material. The invention of this explosive was undoubtedly a huge contribution to the society of the 19th century at that time. This invention also made Nobel a billionaire with many patents for explosives.
Just when glycerin explosives were all the rage, there was an explosives factory in the UK, and they appeared one after anotherEmployees after hoursSudden cardiac death. Later, after research, medical scientists found that these people themselves had heart problems, but when they went to work, they were exposed to nitroglycerin, which can just dilate the blood vessels on the heart and relieve cardiac ischemia angina.
This discovery was remarkable at the time, because until now, nitroglycerin is the first choice for acute attacks of angina pectoris in medicine. At that time, although nitroglycerin was discovered, it can dilate the blood vessels of the heart ** angina, but why does nitroglycerin have this effect, this question has plagued the medical community for nearly a century.
It wasn't until the 20th century that 3 scientists unlocked this mystery. It turns out that it is because nitroglycerin enters our body and will be converted into a vasoactive factor, which can promote vasodilation and relieve angina, and the name of this active factor is calledNitric oxide (NO).
The three scientists who discovered that nitroglycerin can be converted into NO eventually won the Nobel Prize in Medical Physiology in 1998. Not long after this study came out, Pfizer in the United States used this theory to study Viagra, of course, Viagra was not called Viagra at that time, he had a research code name called uk92480, what is this drug used for, it is still related to the heart, it is used to study **angina.
But in the end, it was found that this medicine ** angina is not very good, but has a good ** effect on men's dysfunction. This discovery was also revolutionary at the time, because at that time there was no oral drug in the world that could **dysfunction, so UK92480 was taken seriously by the medical community. After continuous research, it was studied why it can be dysfunctional, and it was later found that it was still related to the aforementioned NO, and the importance of NO at this moment was recognized by the medical community.
Immediately after, around the principle of action of NO, finally UK92480 was upgraded and improved into Viagra, that is, in 1998, UK92480 was listed in the United States, and in 2000, it was listed in China, the trade name is called viagra in English, and the Chinese translation is Viagra.
And it was Viagra that had to be marketed later, and then tadalafil had to be listed, so everyone found that no, if there was no Nobel Prize, there would be no no discovery. And if NO, as such an important vasoactive factor, had not been discovered, Viagra would not have been upgraded and improved, let alone the later tadalafil. Therefore, nitric oxide is the "father" of sildenafil and tadalafil, and without "father", these "two sons" would not be produced.
So let us pay tribute to Nobel, pay tribute to the scientists who discovered NO, and let us treat sildenafil and tadalafil from a different point of view, because their emergence is revolutionary of the times, and there are countless generations of scientists behind the disdainful efforts of scientists, let us remember them.