The researchers found that the high blood pressure drug ramenidine can slow down the aging of worms **twitter).
Researchers have found that the high blood pressure drug ramenidine can slow down the aging of helminths, which increases the likelihood that it may have a similar effect in humans, potentially promoting a longer life and healthier life.
Previous studies have shown that ramenidine mimics the effects of reducing calorie intake, a practice known to extend the lifespan of a variety of animals.
For the first time, we were able to demonstrate in animals that ramenidine can prolong life," says Jo Opedro Magalhes, a molecular biology gerontologist at the University of Birmingham in the UK.
We are now keen to explore whether ramenidine has other clinical applications.
Does ramenidine also delay aging in humans?
While it's unclear whether these findings apply to humans, and if there are health risks involved, scientists hope to find ways to achieve these benefits without resorting to extreme calorie restriction.
In a January study, worms treated with riminidine (commonly used for high blood pressure) showed longer lifespans and improved health indicators, similar to the effects of calorie restriction.
Jo O Pedro Magalh, a molecular biology gerontologist at the University of Birmingham, expressed excitement about the study, highlighting the potential of ramenidine to prolong life.
The study also showed that the drug affected gene activity associated with caloric restriction in kidney and liver tissues in mice.
Identification of key biological receptors.
In addition, scientists have discovered a key biological receptor, NISH-1, which is essential for the effectiveness of ramenidine in prolonging life.
The removal of NISH-1 eliminated the positive effects of the drug, and at the same time restored the receptors, restored the longevity of ramenidine **.
We found that when NISH-1 was removed, the life-lengthening effect of ramenidine was eliminated," the researchers explained in their **. Crucially, rescuing NISH-1 receptors restored the increase in lifespan after using ramenidine**.
Compared to challenging low-calorie diets, riminidine holds promise as an anti-aging drug due to its oral administration, wide range of prescriptions, and relatively mild and rare***. While the study is still in its early stages, these findings provide valuable insights into the future anti-aging potential of ramenidine.