Helicobacter pylori, known as HP (hereinafter referred to as HP), was first reported in 1983 as a gram-negative microaerophilic bacterium colonizing the gastric mucosa, and is the main factor inducing peptic ulcer, chronic gastritis, gastric mucosa-associated lymphoid tissue lymphoma and gastric cancer.
At present, due to the widespread use of standard triple ** and other anti-HP regimens, the resistance rate of HP to antibiotics is increasing day by day, which significantly reduces the ** rate of HP, which brings certain difficulties to **, and the search for new ** drugs and improved ** programs have become an urgent problem to be solved.
In recent years, the application of probiotic preparations has provided new ideas for the prevention and treatment of HP infection, and studies have found that probiotics can improve the HP rate of triple regimens, which is of great significance for the prevention and treatment of gastric cancer, and has become the focus of today's research.
Mechanism of action of Lactobacillus reuteri probiotics to increase HP** rate
The reason why Lactobacillus reuteri probiotics can increase the ** rate of HP can be summarized simply:
Competitive inhibition of HP and gastric mucosal epithelial cell adhesion, inhibition of inflammation caused by HP, inhibition or direct killing of HP. It can also improve the microecological environment of the gastrointestinal tract, reduce the adverse reactions of antibiotics, and then improve the compliance of patients.
This mechanism is mainly implemented in the following aspects:
1.Competitive adhesion
HP penetrates a thick layer of mucus through flagella and adheres to the epithelial cells of the gastric mucosa layer with the help of lipopolysaccharides, adhesin and pili, and the membrane proteins of HP are also involved in the adhesion to epithelial cells, which is an important factor in the pathogenesis of HP. Probiotics compete with HP for mucosal epithelial cell binding sites, thereby reducing epithelial cell adhesion.
It is believed that probiotics may hinder the adhesion of HP to gastric epithelial cells by secreting some active substances that resist bacterial adhesion or some antibacterial substances.
2.Anti-inflammatory effect
In somatic cells, the protein encoded by the related gene A (CAGA) is an important factor in HP infection. The Lactobacillus salivarius in probiotics can inhibit the expression of caga protein, thereby reducing the inflammatory response of the gastric mucosa.
At the same time, probiotics may also enhance the body's resistance to pathogenic microorganisms and enhance the intestinal barrier function by regulating the body's immune response. Some probiotics can also stimulate the mucosa of the gastrointestinal tract to produce secretory IgA, improve the defense function of the gastrointestinal mucosa, and enhance immunity to HP.
3.Inhibits or directly kills HP
For example, lactobacilli can produce some bacteriocins, organic acids (lactic acid, formic acid, acetic acid and propionic acid, etc.) and short-chain fatty acids, which can inhibit or even kill HP, and can reduce the activity of urease and inhibit the colonization and growth of HP in the gastric mucosa. In addition, Bacillus subtilis, Bifidobacterium, Enterococcus faecalis, and Lactobacillus all release bacteriocins with anti-HP activity.
4.Regulates intestinal flora and reduces adverse reactions
Probiotics can regulate intestinal flora imbalance, maintain the balance of intestinal microecology, prevent antibiotic-related diarrhea and constipation, etc., thereby improving the compliance of patients.
Probiotics can improve the tightness of the junction of gastrointestinal mucosal epithelial cells, prevent the translocation of intestinal bacteria, and improve the barrier function of the mucosa. In addition, the nutrients released by probiotics are able to provide nutrients to the epithelial cells of the gastrointestinal tract.
Why should I choose Lactobacillus reuteri DSM7648 against Helicobacter pylori?
Microbiome is the closest thing to perfection for H. pylori, but this can only be done with specific probiotics. Studies have confirmed that Lactobacillus reuteri DSM7648 can fight against Helicobacter pylori in the body, reduce the number of bacteria, and protect gastrointestinal health.
Mechanism of action of Lactobacillus reuteri DSM7648
The adhesion molecules of Helicobacter pylori recognize and adhere to the surface and physically ** and entangle with Helicobacter pylori in the stomach to form an insoluble polymer that is excreted through the digestive tract, thereby reducing the number of Helicobacter pylori and reducing the risk of gastritis, gastric ulcer and gastric cancer.
Lactobacillus reuteri Pylopass is certified by the Presumption of Reasonable Safety (QPS) (EU)-GRAS (USA) and halal certification for use as a dietary supplement.
At the same time, Lactobacillus reuteri has won a number of national invention patents in Germany, China, Japan and other countries, which is a new method to inhibit Helicobacter pylori that is different from traditional methods such as antibiotics.
Compared with other probiotic preparations, Lactobacillus reuteri DSM7648 is safe and natural, easy to store, and will not interfere with the balance of normal microorganisms in the intestine after taking it, so there is no need to worry about gastrointestinal flora imbalance. Compared with other probiotic products, the culture is more stable and does not require cumbersome refrigeration.
Effect of egg yolk immunoglobulin on Helicobacter pylori?
Egg yolk immunoglobulin (IGY) has made it a popular research area for antibody production due to its molecular structure and biological advantages. By immunizing laying hens, the corresponding antibodies can be obtained from the yolk produced by them, and can be used for the prevention of the corresponding diseases, such preparations are called yolk antibodies (IgY).
A large number of experimental studies have shown that HP-Igy can eliminate Helicobacter pylori in a targeted manner, and has obvious anti-inflammatory effects on inflammatory reactions such as gastritis, gastric ulcer, and duodenal ulcer. In addition, IGY can improve human body function, improve immunity and thus promote human health.
Why does Xie You'an add the ingredient of immortal berries?
Proanthocyanidins contained in Ageless Berry Radiation Resistance Mechanism
The free radical theory of radiation damage believes that radiation can lead to the production of a large number of reactive oxygen species in the body, and these highly reactive free radicals can damage cell DNA, biofilm and other biological macromolecules, resulting in a series of pathological damages such as cell peroxidation damage, cell dysfunction, cell cycle disorders, and cell necrosis and apoptosis. Proanthocyanidins (GSP) is a class of natural plant polyphenolic compounds, which has the advantages of non-toxic, high efficiency and high bioavailability, and is one of the most powerful natural antioxidants found by humans from nature so far, with strong antioxidant and free radical scavenging activities, as well as a series of other excellent biopharmacological effects such as cell protection and anti-tumor.
Now the Russian space industry has also begun to study the use of berries to improve the diet of astronauts, in order to help astronauts better resist the damage of space and other radiation. Moreover, the seventh R&D team of the European Union has also confirmed through experimental studies that anthocyanins can effectively resist tissue radiation damage during chemotherapy and radiotherapy for some cancers.
The fruit of the berry has extraordinary health benefits
According to the research of the professors of the Polish National Medical University and the Warsaw Medical University, it was concluded that the proanthocyanidins, polyphenols, flavonoids, vitamins and minerals needed by the human body are rich in proanthocyanidins, polyphenols, flavonoids, and minerals required by the human body, and the antioxidant index ranks first among more than 200 kinds of fruits. Its rich and unique nutrients have significant effects in many aspects of beauty and beauty, anti-aging, anti-cancer, reducing the three highs, and moisturizing the intestines. It is known as an anti-cancer agent in nature, an immortal artifact in the beauty industry, and a health dream pursued by people with three highs and obesity.
Berries are rich in anthocyanins and flavonoids (and their sugar camps) that help keep the urinary tract healthy;It is also rich in vitamins and has anti-aging properties. The fruit extract has a good effect on radiation sickness and heavy metal poisoning. Berries can be used in the production of "juices", as well as other popular soft drinks, the most attractive feature of which is its dark purple color, which shows a high content of anthocyanins, a natural pigment.
The three major mechanisms of action of Xie You'an:
Clearing] Lactobacillus reuteri DSM17648: As a patented bacterium, Lactobacillus reuteri DSM17648 can specifically recognize and anchor the bacterial membrane receptor of Helicobacter pylori, and physically ** and winding to form an insoluble polymer, so that Helicobacter pylori cannot be fixed on the wall of the pylori and thus excreted from the body.
Antibacterial] egg yolk immunoglobulin IGY: egg yolk immunoglobulin IGY can bind to the target of Helicobacter pylori, so that it loses its pathogenicity, and can neutralize the toxin cytotoxicity of Helicobacter pylori, reduce or damage to cells, enhance the inhibitory effect of the gastrointestinal tract on Helicobacter pylori, and have a protective and repairing effect on the gastrointestinal tract.
Protection] Berry Ultra Micro Freeze-Dried Powder: Berry can strengthen the immune system, reduce the occurrence of colds and flu, and protect the gastric mucosa. Because the flavonoids it contains have anti-inflammatory properties that can defeat bacteria and viruses, its anti-inflammatory effect is mainly by inhibiting the expression of endothelial cell adhesion molecules, which has a definite gastrointestinal protective function.
Solution: It can be used to prevent and deal with Helicobacter pylori infection, and can also be used with quadruple **to improve** the effect of Helicobacter pylori.
It is especially suitable for:
1.HP-infected people who have failed antibiotics**;2.Populations with multiple ** HP infections that are resistant to antibiotics;3.People with HP infection who are not sensitive to antibiotics;
4.People with HP infection who do not want to take antibiotics ** worry ***;5.Young and older groups who are not candidates for antibiotics**.