Lupus erythematosus is, in a sense, the result of a combination of genetic, hormonal, and environmental factors.
Scientists have discovered more than 50 genes associated with lupus erythematosus, which are like special codes in the body that may make people more susceptible to the disease.
If someone in the family has had lupus, members of the family may be more likely to get lupus.
But having these genes doesn't necessarily mean you get sick, like a pair of twins with these genes, one may get lupus erythematosus, and the other may not.
Lupus erythematosus is more common in women, and scientists have found that it may be caused by estrogen.
Although there is no evidence yet that there is a direct causal relationship between estrogen or any other hormone and lupus.
But many women experience more severe lupus symptoms during premenstrual periods or pregnancy when estrogen levels are high, suggesting that hormones may play a role in regulating lupus activity.
In addition to genes and hormones, environmental factors can also be one of the triggers for lupus erythematosus.
For example, the sun's ultraviolet rays, certain infections, or taking certain medications can be external causes of the disease.