CA125 is a glycoprotein discovered by American scientists, in 1981, scientists used an antibody called OC125 to discover a protein that is ** in ovarian serous cancer cells, named CA125.
CA125 is a special tumor marker, which has always been considered an important indicator for the diagnosis of ovarian cancer, and has important significance in the diagnosis of ovarian cancer.
However, CA125 is not only elevated in ovarian cancer, but can also be seen in some other malignant tumors. Today we will talk about it in detail.
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Significance of CA125 in ovarian cancer.
CA125 has certain specificity and sensitivity for ovarian cancer, and clinical investigations have shown that there are many patients with ovarian cancer who can detect a significant increase in CA125, especially ovarian epithelial cancer, which may be elevated at an early stage.
However, we can also see that some patients do not have an increase in Ca125, or the increase is not significant.
Therefore, although CA125 has a certain specificity for ovarian cancer, this specificity is not high, so we usually do not use CA125 as the main screening method for ovarian cancer, but only as an important reference index.
Although it has a limited role in screening, CA125 can play a very important reference role in the ** period of ovarian cancer.
For ovarian cancer patients with significantly elevated CA125, her CA125 value is generally proportional to the activity of the tumor, and with the progress of **, the tumor activity decreases, and the CA125 value will gradually decrease, or even drop to the normal level. In the case of ovarian cancer** and metastasis, the CA125 value will also increase.
Therefore, the detection of CA125 value has a very important reference significance for evaluating the effect and judging the quality and metastasis of ovarian cancer.
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Significance of CA125 in other malignancies.
In addition to ovarian cancer, CA125 may also be elevated in some other malignant tumors, such as cervical cancer, breast cancer, pancreatic cancer, liver cancer, gastric cancer, colorectal cancer, etc.
Therefore, if CA125 is found to be elevated, not only ovarian cancer should be considered, but also the possibility of other malignant tumors.
CA125 is not highly sensitive in other malignancies, so it is only used as a reference auxiliary test item for disease suggestion, and is not used as the main diagnostic basis.
CA125 is also only used as a reference item in the ** and subsequent re-examination of other malignant tumors, but caution should be taken if the value is significantly elevated.
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In addition to malignant tumors, some benign diseases will also have an increase in CA125, such as uterine fibroids, inflammation, liver cirrhosis, diabetes, etc., especially in diseases and pelvic inflammation, CA125 is often elevated.
Therefore, the elevation of Ca125 is not necessarily a malignant tumor, and benign diseases can also cause an elevation of Ca125.
So how do you distinguish between benign and vicious?
Let's start by looking at the CA125 elevated value.
In general, the increase in CA125 caused by benign diseases is usually only a little higher than the normal value, not too much; The CA125 increase caused by malignant tumors is usually relatively high, and this increase is doubled, the normal value of CA125 is 35, and the increase caused by malignant tumors is usually more than 70, or even hundreds, or even thousands.
In addition to looking at the numerical values, we also need to look at other tumor marker tests.
In general, the elevation of CA125 caused by benign diseases is a single elevation, and the elevation of other tumor markers rarely occurs; Sometimes we will find that the CA125 value is only a little higher, but there are several other tumor markers that are elevated, and we should also consider the possibility of malignant tumors.
Another point is to see if the CA125 value continues to increase.
The elevation of CA125 caused by benign diseases is transient, short-term elevation, and the examination is elevated this month, and it will be normal next month; The increase in CA125 caused by malignant tumors is a continuous increase, and it will continue to increase progressively over time, this month's examination may be 70, next month may be more than 100, and then the next month may be higher.
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Finally, let's talk about the question, that is, the higher the CA125 value in ovarian cancer patients, the higher the degree of malignancy?
No, the value of CA125 is not directly related to the malignancy of the tumor, and we can see in clinical practice that some ovarian cancer patients with a very high degree of malignancy have a low CA125.
Therefore, we cannot judge the malignancy of the tumor simply by the CA125 value, and the malignancy of ovarian cancer in different patients is not directly related to the CA125 value.
However, we need to know that the CA125 value of the same patient at different times is very meaningful for judging the condition and can indicate the change of our condition.
Some of the content about CA125 is shared here, if you have any questions in this regard, you can raise them, let's talk about them together.