During World War II, because of the backward purification technology, penicillin, as a key battlefield trauma drug, once reached 270 times that of the time at that time, as high as 840 pounds per gram, and only the leaders above the Allied brigadier general could be equipped with two in Europe. But only a year has passed, and British scientists have innovated fermentation technology, making the monthly output of penicillin more than 1 trillion units, more than 99% of penicillin **instantly**, and only 1 pound per piece.
In the past ten years since 2013, the "Leyuetai" anti-aging enzyme discovered by the laboratory of Harvard University has also experienced a process from sky-high price to parity, and after the cost dropped by 95%, Jingdong handed over a satisfactory sales data during the promotion period. It is expected to benefit nearly 300 million of the world's aging population.
According to the data, the Leyuetai substance, known as the anti-aging enzyme, is a substance with the scientific name of nicotinamide mononucleotide, which has been experimentally confirmed to be effective at the level of coenzyme NAD+ molecules in the body.
In 2013, Sinclair, a professor of genetics known as the "godfather of anti-aging", found in his study that providing the substance to experimental mice for 1 week can make 24-month-old mice show the physiological state of 6-month-old mice in the experiment, and a number of aging indicators in the body have changed to a younger state, including a number of key indicators such as mitochondrial function and strength.
The results of this study caused an uproar when they were first published in Cell, leading to a hot topic in the field of anti-aging in the past decade. In 2014, Sinclair was published by Time magazine in the United States for its contribution to solving the global aging problem.
However, on the road from the laboratory to the commercial market, Leyuetai anti-aging enzyme has encountered many obstacles. Although financial tycoons have invested heavily in the research and development of supplements, due to the limitations of the extraction method at that time, the cost of anti-aging enzymes is very high.
As an ingredient that can only be extracted from natural plants, to extract 1g of anti-aging enzyme, it is necessary to process about 15,340 kg of avocado or 43,478 kg of broccoli, which the German ** merchant Sigma-Aldrich has given a whopping 23,741 per gram of extract**.
Because of the high cost, only the wealthy at the top of the pyramid could afford the cost of this technology. Hong Kong Li invested 1.56 million yuan in the trial, and said that "I seem to be 20 years younger", and added 200 million yuan to promote the research. International superstar Madonna and former richest man Bill Gates have also publicly expressed their loyal support for anti-aging enzymes.
Thanks to the investment of the rich, the production process of anti-aging enzyme has undergone many changes in recent years, from plant extraction method to biological enzyme synthesis method, and the cost has been reduced by more than 95%.
Jingdong's product page shows that Leyuetai anti-aging enzyme has dropped to 1,000 yuan. The Harvard University laboratory cooperated with Regenerative Bio, a Boston-based company that is the first in the world to combine AI pharmaceutical-related technologies with biology, to introduce the world's leading AI technology and organ aging clock model into the production of Leyuetai anti-aging enzymes, reducing production costs and improving bioavailability.
Technological iteration has brought about a decline in the world, so that the market coverage of Leyuetai anti-aging enzyme extends from a small number of people at the top of the pyramid to the middle class in first- and second-tier cities. Jingdong Shangzhi data shows that Leyuetai's core user base is concentrated in 35 to 59 years old.
First- and second-tier elites, including workers in finance, information technology, e-commerce and other fields.
Since 2013, 136 articles on anti-aging enzymes have been published in top journals such as "Nature" and "Cell", all of which are due to the serious aging of the world, and the world's pursuit of "old without disease, old without aging" is becoming increasingly enthusiastic.
In 2023, Pencina KM et al. conducted a study on "Safety and physiological effects of increasing NAD+ levels by oral NAD+ precursors in age-related disease risk**". The results showed that NAD+ precursors safely increased circulating NAD+ levels and significantly reduced total LDL, cholesterol, non-HDL cholesterol, body weight, and diastolic blood pressure in overweight or obese middle-aged and older adults.
These data provide a strong theoretical basis for the effect of Leyuetai anti-aging enzyme. The research team of Shinichiro Imai at the University of Washington also demonstrated the relevant experimental results in animal models, and the life expectancy of experimental animals increased by 23 times.
In the past two years, the trading volume of anti-aging enzymes on the Jingdong platform has continued to climb, becoming a new dark horse in the consumer market.
Research shows that in the next five years, the compound annual growth rate of this field will reach 7025%, coupled with the continuous improvement of global health awareness in the past three years, it is estimated that the future market size can reach 273200 million, more than 300 million people will benefit from it.
According to the "2021 Luxury Users*** Among the user groups with a single consumption of more than 1,000 yuan, male consumers account for 55%, highlighting the characteristics of this group's ** value and low frequency. When the male group begins to learn to "please themselves", Leyuetai, which is in the top five on the Jingdong platform, is only the tip of the iceberg to show their economic strength.