Chinese name: CBR-5884
Product Name: ethyl 5-(2-furoylamino)-3-methyl-4-thiocyanato-2-thiophenecarboxylate
CAS Number: 681159-27-3
MF: C14H12N2O4S2
Molecular weight: 33638
Storage conditions: 2-8
Uses: For scientific research only, not for human use.
CBR-5884 is a chemical that has been found to be a potent inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH). Under experimental conditions, CBR-5884 shows inhibition of PHGDH with an IC50 value of 33 M. This means that CBR-5884 can inhibit PHGDHase activity by 50% at a concentration of 33 M. This discovery is of great scientific significance, as it provides an effective tool for studying the function and regulatory mechanisms of PHGDH in living organisms.
The discovery of CBR-5884 marks a major breakthrough in the development of novel drugs. PHGDH is an enzyme that plays an important role in many biological processes, including DNA synthesis, cell proliferation, and tumor development. Therefore, the development of drugs that inhibit PHGDH is expected to be an effective method for cancer and other diseases. The discovery of CBR-5884 provides new ideas and tools for research in this field, which will help promote the development process of related drugs.