Gastric mucosal protector refers to drugs that have the effect of preventing and improving gastric mucosal damage, protecting the gastric mucosa, and promoting tissue repair and ulcer healing. Different gastric mucosal protectors have their own different characteristics, and clinically it is necessary to reasonably select the types of gastric mucosal protectors according to the specific conditions of patients and the different characteristics of drugs. Mucosal protectors, according to the pharmacokinetic mode of action, are divided into endogenous and exogenous mucosal protectors.
1: Exogenous mucosal protector.
Mainly including aluminum-magnesium and bismuth, such drugs can promote mucus secretion and increase bicarbonate content, and through local action, play a role in neutralizing gastric acid, reducing pepsin activity and strengthening the mucosal barrier.
2: Endogenous mucosal protector.
These include columnar cell stabilizers, gastrointestinal hormones, antioxidants, and glutamine. Such drugs can enter the bloodstream and exert systemic effects, externally defend against gastric acid erosion, and internally repair mucosal damage; It mainly plays a role through mechanisms such as stabilizing cell membranes, increasing submucosal protective factors, increasing mucosal blood flow, and antioxidant [1], and may also have a certain protective effect on the small intestinal mucosa in addition to protecting the gastric mucosa. Gastrointestinal mucosa