Product name: mercaptan polyethylene glycol hydroxyl.
Product name: thiol-peg-oh, MW: 2000
Thiol-PEG-OH is a polymeric PEG derivative, in which:"thiol"Indicates that the terminal has a mercaptan (-sh) functional group, while"oh"Indicates that the end also has a hydroxyl (-OH) functional group. Its molar mass is 2000 grams.
This polymer is often used as an intermediary or carrier in the biomedical and drug delivery fields. The thiol-peg-OH has strong nucleophilic and reactivity, and can undergo addition reactions with molecules containing double bonds or halogen functional groups to form stable thioether bonds or thioester bonds. Whereas, the hydroxyl functional group increases its solubility and biocompatibility.
Thiol-Peg-OH can be used as a modifier for drugs, through the reaction of thiol functional groups with drug molecules, to achieve the modification or modification of drugs, so as to improve the solubility, stability or targeted delivery performance of drugs. In addition, Thiol-PEG-OH can also be used as a surface modifier for biomedical materials to improve their biocompatibility.
Overall, thiol-peg-OH is an important biomedical material with a variety of potential applications, including drug delivery, tissue engineering, biosensing, and biomaterials.
Thiol is an organic functional group, also known as sulfhydryl or sulfide group, with the chemical formula -RSH, where R stands for organic group. The thiol molecule is formed by the combination of a sulfur atom with a hydrogen atom on a carbon atom to form a sulfur-hydrogen bond.
Mercaptan is a nucleophile that has strong electrophilicity. They can undergo addition reactions with many compounds to form compounds such as thioethers (S-S), thioesters, and more. Due to their activity, thiols have a wide range of applications in fields such as biochemistry, organic synthesis, and materials science, such as as reducing agents, crosslinkers, protective groups, and part of drug delivery systems.
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: Qi Yue Hao February 20, 2024.