Introduction:
HRG (Histidine-rich glycoprotein), that is, histidine-rich glycoprotein, is a multifunctional glycoprotein found in plasma. It has a variety of biological functions, including promoting platelet aggregation and thrombosis, regulating immune responses, and promoting cell proliferation. The biological function of HRGs has attracted a lot of interest in the medical field, especially in the areas of cancer and immunity. In recent years, scientists have successfully synthesized the recombinant protein of HRG through recombinant technology and conducted in-depth research on its biological functions. Catalog No. PA1000-7610
A comprehensive introduction to HRG recombinant proteins:
HRG recombinant protein is a protein that is expressed and purified by genetic engineering technology in expression systems such as Escherichia coli. Compared with natural HRG proteins, recombinant proteins have higher purity and stability, which can be better used in laboratory research and clinical applications**. The structure of the HRG recombinant protein is similar to that of the native HRG protein, which is mainly composed of a polypeptide chain and a glycan group containing histidine. Studies have shown that HRG recombinant proteins not only have the biological functions of natural HRG proteins, but also have stronger activity and a wider range of applications.
Application of HRG recombinant proteins in biological functions:
1.Promote platelet agglutination and thrombosis: HRG recombinant proteins can bind to coagulation factors and platelet surface receptors to promote platelet aggregation and thrombosis processes. This function makes HRG recombinant protein have potential applications in blood clotting diseases and the prevention of cardiovascular diseases.
2.Modulation of immune response: Studies have found that HRG recombinant proteins can regulate the activity of immune cells and affect inflammatory responses and immunomodulatory processes. This effect makes HRG recombinant proteins important in autoimmune diseases and immunity**.
3.Promote cell proliferation and repair: HRG recombinant proteins have proliferative and repair effects on a variety of cell types, including nerve cells, cells, and ** cells. This makes HRG recombinant proteins have a broad application prospect in the field of tissue engineering and repair.
Conclusion: Through a comprehensive introduction to HRG recombinant protein and an in-depth analysis of its application in biological functions, we can see that this new protein has broad application prospects in the medical field. In the future, with the further research and development of HRG recombinant protein, it is believed that it will bring new breakthroughs and hope in the fields of cancer, immunity, and tissue repair.
References: 1 gebremeskel s, and shukla hd. histidine-rich glycoprotein: the swiss army knife of mammalian plasma. blood. 2013;121(11): 1942-1951.
2. pluskota e, et al. discovery of novel histidine-rich scaffolds for heparin binding and triggered release of growth factors. biomaterials. 2018;178:50-60.
3. menezes j, et al. histidine-rich glycoprotein: a potential therapeutic agent for sepsis? shock. 2017;47(1):3-9.