Department of Clinical Laboratory, Science City Hospital, Sichuan Province.
RecentlyA rare case of blood group b(a) was identified.
(Click to review).And recently,Taizhou City, Jiangsu Province
Found than "dinosaur blood".Also rare blood types
Small P blood type!
Cao Guoping, 59 years old, is the director of the blood transfusion department of Taixing People's Hospital in Jiangsu Province.
Discovering this little plutonic blood type was both tortuous and lucky. Cao Guoping introduced that he had encountered this special blood type many years ago, and found that it was a small P blood type, and for various reasons, he could not conduct further genetic analysis.
Routine blood grouping.
Identification of irregular antibodies (anti-TJA antibodies).
Miraculously, many years later, during a blood test, Cao Guoping discovered this special blood type again. "This kind of blood and the recipient of the blood are not successful, out of professional instinct, I suddenly thought of the person back then, and after careful inspection, it was really the same person. ”
This time, Cao Guoping paid special attention to it, and after testing, it was confirmed again that this person was a very rare small P blood typeHe is the first person in Taizhou so far. According to records, in the Chinese population, rh-negative blood "panda blood" is about 04%, "dinosaur blood" is about 1 to 1 in 100,000, and the frequency of small P blood type is less than 1 in 1 million. At present, there are only 9 people with the small P blood type recorded in China, which is quite rare.
At the same time, Cao Guoping performed genetic sequencing on this blood.
Something even more amazing happened. Cao Guoping found that the gene sequencing results in this case were not the same as all the reported results of the small P blood group gene mutations.
In December last year, Cao Guoping sent the sequencing results to a human gene bank in the United StatesA nucleotide sequence that has not been discovered globally since the discovery of this rare small P blood group was identified and assigned the serial number OR900206 by the gene bank.
This brand-new discovery is of great clinical value!
Small classes
In life, we usually know ABO blood group and Rh negative blood type (panda blood), but we know little about other blood types, such as "dinosaur blood" - Bombay blood type, "* blood" - rhnull, A3 blood type of subtype A (currently only 1 person in the world - Nanjing, China) and small P blood type are known as the 4 rare blood types in addition to "panda blood".
The P blood group was discovered in 1927 by the Austrian biologist Landsteiner. At present, there are 7 subtypes of P blood type (P1, P2, LEK+, LEK-, P, P1K, P2K), the first 4 are common in the population, and the last 3 are rare. Among them, the small P blood group red blood cells lack all P-specific antigens, and anti-TJA antibodies are present in the serum.
Clinically, if the general patient receives blood containing TJA antibody (small P blood type), it will cause hemolytic transfusion reaction, on the contrary, when a person with small P blood type needs blood transfusion, he can only receive ABO type or O type and must also be small P blood type, otherwise it will cause a severe hemolytic transfusion reaction and be life-threatening. In the case of women, it can lead to recurrent miscarriages and stillbirths.
*: Youth Shanghai.
Editor: Xu Weichen
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