This article is organized by Shandong Quankeruida Instrument Co., Ltd.
Transdermal patch is a kind of preparation administered by **, and its adhesion is one of the important indicators to evaluate its quality and efficacy. Therefore, the detection of transdermal adhesion is crucial. In this article, the detection methods and testing instruments of transdermal adhesive adhesion will be introduced.
1. Detection method of transdermal adhesive adhesion.
1.Manual testing method.
Manual testing is the simplest and most straightforward method for testing adhesion of transdermal patches. This method evaluates the adhesion of transdermal patches primarily by observation and feel. The specific operation is as follows: paste the transdermal patch on the **, then press it by hand for a period of time, and after its adhesion is firm, slowly tear it off to observe its adhesion effect. Although this method is simple and easy to implement, it is highly subjective and has a large error, and cannot accurately reflect the adhesion of transdermal patches.
2.Tensile tester detection method.
The tensile tester test method is a relatively accurate method for testing the adhesion of transdermal patches. This method mainly uses a tensile tester to perform a tensile test on the transdermal patch to measure the force required during the tearing process. The specific operation is as follows: paste the transdermal patch on the sample stage of the tensile tester, set the tensile speed and distance, and then start the instrument to perform the tensile test and record the force value of the transdermal patch when it is torn. This method can accurately reflect the adhesion of transdermal patches, but the equipment cost is high and the operation is complicated.
3.Adhesion tester detection method.
Adhesion tester is a professional transdermal adhesive testing method. This method tests the transdermal patch with an adhesion tester to measure the maximum load it can withstand per unit area. The specific operation is as follows: paste the transdermal patch on the test plate of the adhesion tester, adjust the angle and distance of the test plate, start the instrument for testing, and record the maximum load of the transdermal patch during the tearing process. This method can accurately reflect the adhesion of transdermal patches, and the equipment cost is relatively low and easy to operate.
2. Transdermal adhesive adhesion testing instrument.
1.Tensile tester.
The tensile tester is a professional mechanical property testing instrument, which can measure the performance indicators of materials under different stress states such as tensile, compression, and bending. In the adhesion test of transdermal patches, the tensile tester is mainly used to measure the force value of the transdermal patch during the tearing process to evaluate its adhesion. The main components of the tensile tester include: force measurement system, sensor, drive system and computer control system, etc. The force measurement system is mainly responsible for measuring the force value, the sensor converts the force value into an electrical signal, the drive system controls the tension or compression of the sample, and the computer control system collects and processes the data, and outputs the test results.
2.Adhesion tester.
An adhesion tester is an instrument specifically designed to measure the adhesion of materials. In the adhesion testing of transdermal patches, the adhesion tester is mainly used to measure the adhesion of transdermal patches under different conditions. The main components of the adhesion tester include: test plates, sensors, drive systems and computer control systems. The test board is used to fix the transdermal patch sample, the sensor measures the force between the sample and the test plate, the drive system controls the movement of the test board, and the computer control system collects and processes the data, and outputs the test results.
3.Other ancillary equipment.
In addition to the tensile tester and adhesion tester, the adhesion test of transdermal patches requires some auxiliary equipment. For example: **Simulation membrane, constant temperature and humidity chamber, etc. These devices are mainly used to simulate the actual use environment and improve the reliability of test results.