Introduction
Human fibroblast interferon, also known as interferon, is produced by fibroblasts and other cells after induction by viruses, nucleic acids, etc., and binds to the same receptor as interferon, with similar biological effects.
Indications
The amino acid structure of interferon is different from that of interferon A, and the two interferons recognize the same cell surface receptor. In vitro, interferon has a greater antiproliferative effect on some cells than interferon a. Phase clinical trials of interferon are also underway. Toxicity is similar to that of interferon A preparations.
Latest research
In November 2012, researchers discovered that blind mole rats may not see, but they are pointing the way to conquering cancer. Moles are never cancer-free, which allows them to survive 7 times longer than most rodents. Experiments with cells from the Judah mountain blind mole and the Golan highland blind mole have shown that these animals have a unique ability to kill cells that proliferate too quickly. A team led by Vera Gobunova of the University of Rochester in New York used growth fluid to grow fibroblasts of mole rats that resemble ** cells and found that once these cells proliferate to a certain extent, moles secrete a suicidal substance, interferon, which causes these cells to die quickly. Previously, the team confirmed that another way for moles (naked mole rats) to fight cancer is to confine cells when they are tightly clustered (as is the case with tumors). The researchers hope to find out how moles fight cancer by exposing blind mole rats to cancer-causing chemicals. Panelist Andrei Seroanov said this could open up new avenues for human anti-cancer research, finding drugs that trigger cell suicide and applying them to cancer cells.