Elevated protein in urine does not necessarily indicate impaired renal function, mainly glomerular basement membrane damage, so urine protein and hematuria alone are better controlled. But if creatinine is also elevated, it's a different story. In addition to the pathological damage of the glomeruli, the overall kidney function has also been significantly damaged, and it is necessary to protect the kidney in a timely manner.
Many kidney friends are concerned about this question: "Does creatinine and urine protein increase at the same time, does it mean that kidney disease is very serious?" ”
Indeed, the abnormality of these two troubling indicators at the same time indicates that there is both pathological damage to the kidneys and impairment of overall kidney function, and it continues to develop. However, whether the specific injury is serious or not needs to be further evaluated and judged, and it does not mean that the higher the index, the more serious the condition.
Did you see that your hanging heart was half relieved of this? Creatinine and urine protein are two indicators that reflect different stages of development of renal function, and the response is different in terms of disease development. Creatinine is more responsive to increased levels of endotoxins in the blood following impaired renal function, whereas protein in the urine is a response to glomerular injury and decreased glomerular filtration.
After both of these indicators are elevated, renal function can still be stabilized, and it does not necessarily develop in the direction of uremia. Then in the process of protecting the kidney, these problems should also be paid more attention:
1. After creatinine increases, attention is paid to the improvement of detoxification function
After the creatinine rises, the filtration function of the kidneys has begun to decline, and the excretion rate of excess small molecule toxins is slowed down, and they are gradually deposited in the blood and cannot be metabolized in time. Long-term accumulation of toxins in the blood and various organs will gradually cause the appearance of abnormal symptoms in the body, accelerate the progression of kidney failure, and increase the risk of uremia.
Elevated levels of toxins in the blood can affect electrolyte levels, acid-base metabolism, blood circulation, and other abnormalities. In order to improve toxin levels and reduce indicators such as creatinine and uric acid, it is necessary to fundamentally improve the detoxification function of the kidneys.
The fundamental function of detoxification is to delay the damage of kidney cells and ensure the blood oxygen of the remaining kidney cells. In terms of medication, more attention should be paid to the stability of blood circulation and anticoagulation**, and at the same time, combined with traditional Chinese medicine to promote blood circulation and eliminate blood stasis, to ensure the stability of kidney blood circulation signals.
2. Attention should be paid to the degree of kidney atrophy
Not all patients in clinical cases have atrophy of the kidneys after elevated creatinine. Renal atrophy is an irreversible damage caused by the development of cellular fibrosis in the kidney to a certain extent, which is generally accompanied by a decrease in renal function damage, but renal atrophy is not caused by abnormal indicators.
Patients with massive proteinuria are mainly active in renal pathology and damage to the basement membrane of the glomeruli, but the disease does not necessarily develop severely, nor does it necessarily have significant renal atrophy.
Many patients in kidney preservation** are unconsciously examined and found that the kidneys have shrunk, and it is difficult to reverse and recover at this time. Therefore, in the case of preventing kidney atrophy, in addition to urine protein and creatinine, there is another indicator to look at, which is the glomerular filtration rate.
Generally, the glomerular filtration rate is between 60-90, and the kidney disease is in the stage, the compensatory stage, and even without significant shrinkage, but there are a small number of people whose filtration rate drops to 70 and the kidney begins to shrink gradually.
Therefore, when it comes to protecting the kidney, it depends on the glomerular filtration rate, and it is necessary to pay attention to correcting the blood flow of the kidney below 75, which is the key to preventing the rapid deterioration of kidney cells and the atrophy of the kidney.
Therefore, the key to stabilizing renal function is not only to control the indicators of creatinine and urine protein, but to control the stability of glomerular filtration, metabolism, detoxification, regulation and other functions and functions as a whole, so as to block the occurrence of uremia.