Acne, what we commonly call "acne", can be described as a troublemaker in the ** world. It not only "camps" in areas with dense sebaceous glands such as the face and back, but also often causes symptoms such as redness, swelling, and pain, which makes many beauty lovers have a headache. As a common disease, the causes of acne are complex, involving a variety of factors such as genetics, androgens, diet and lifestyle habits.
Some people are born with well-developed sebaceous glands and a strong oil secretion, which makes them more susceptible to acne. Androgenic changes, especially during puberty, often trigger acne breakouts. In addition, unhealthy eating habits, staying up late and other bad lifestyle habits can also stimulate the sebaceous glands and promote the formation of acne.
In the face of this stubborn problem, isotretinoin softgels, as a commonly used drug, play an important role in acne.
First of all, isotretinoin softgels help to regulate cell proliferation and differentiation. The formation of acne is related to the excessive proliferation and dysregulation of ** cells, isotretinoin softgels are able to regulate the cell cycle, promote normal cell proliferation and differentiation, thereby reducing the formation of acne lesions. At the same time, isotretinoin softgels can also inhibit the abnormal proliferation of keratinocytes, help to remove the stratum corneum on the surface, and make it smoother and more delicate.
Secondly, isotretinoin also has antibacterial and antikeratinizing effects. The occurrence of acne is related to bacterial infection, and isotretinoin softgels have a certain antibacterial effect, which is able to inhibit the growth of bacteria such as Propionibacterium acnes and further reduce the inflammatory response of acne. At the same time, isotretinoin softgels can also resist keratinization, so that the stratum corneum on the surface of the ** can maintain normal metabolism and renewal, which helps to ** acne and prevent scarring.
In addition, isotretinoin has anti-inflammatory effects. The occurrence of acne is closely related to inflammation, and isotretinoin softgels are able to effectively suppress the inflammatory response, thereby reducing acne symptoms. By inhibiting the production and release of inflammatory factors, isotretinoin softgels help to minimise pores, reduce sebum production, and further promote acne healing.
Isotretinoin plays a leading role in influencing the key links of acne onset, and according to clinical observations, it generally takes effect after 3 to 4 weeks of medication. Pay attention to the following minor issues during the medication to avoid affecting the effect of isotretinoin.
1. Take according to the dosage and dosage
The dosage of isotretinoin is strictly regulated and needs to be calculated based on body weight, so the dosage of oral** varies from person to person. The recommended starting dose of isotretinoin is 025～0.5 mg kg d, according to this standard, a person weighing 50 kg will have a daily dose of 125 25mg, i.e. 1 2 capsules a day, divided into two doses with food. After 2 to 4 weeks of medication, the dose can be adjusted according to the ** effect and adverse reactions of acne.
2. Take with food
Isotretinoin is a fat-soluble drug, and the fat components in food can help the drug absorption, but you don't need to deliberately eat too oily, and a little fat in the meal is fine, so it is recommended to take it with or immediately after a meal.
3. Don't neglect to consolidate**
Generally, the onset of isotretinoin can be observed in 3 to 4 weeks, but this is still the initial stage of **, and the course of medication needs to be formulated according to the control of acne lesions, usually not less than 16 weeks. After the acne lesions are fully controlled, the dose of isotretinoin can be appropriately reduced and continued for 2 to 3 months or longer to consolidate the ** effect.
4. Pay attention to ** nursing
The most common adverse reaction of isotretinoin is mucosal dryness, such as dry lips, cheilitis, dry mouth, dryness, desquamation, etc., which is mainly related to its strong inhibition of sebaceous lipid synthesis, and it is also a sign of the drug's effect, and can also be used as a way for doctors to observe the efficacy of the drug. In addition to drinking more water to ensure water intake during the medication, we should also pay attention to the best care, choose moisturizing products with the best barrier repair function, and use them twice in the morning and evening or as needed. Because isotretinoin is photosensitive, excessive exposure to sunlight may cause allergic manifestations such as burning, itching, erythema, pimples and even blisters, so sunscreen measures should be taken throughout the medication, avoid going out when the sun is exposed to intense sunlight, or holding an umbrella with a hat and applying sunscreen when going out.
5. Adjust your living habits
Common triggers of acne include high-fat and high-sugar diet, lack of sleep, excessive stress and other bad habits.
In short, in order to effectively remove acne through oral isotretinoin, you need to use the drug rationally under the guidance of a doctor, pay attention to the time and dosage of the drug, and at the same time combine other methods and adjust lifestyle habits to achieve the best effect.
References:Chinese Acne ** Guidelines (2019 Revised Edition).