NK cells** is a natural killer cell-based immunity** designed to harness the killing effect of natural killer cells on tumor cells to ** cancer. In recent years, with the in-depth understanding of the biological characteristics of NK cells and the development of immunology technology, NK cells have become a research hotspot in the field of tumor immunity. This article will summarize and provide an overview of the relevant content of NK cells**.
1. The principle of NK cells**.
NK cells are natural killer cells, an important component of the innate immune system, and have the effect of killing tumor cells, viruses and intracellular parasites. The principle of NK cells is to use the killing effect of NK cells to infuse NK cells into patients to eliminate tumor cells in the body, so as to achieve the purpose of **tumor.
2. Classification of NK cells**.
According to the different preparation methods of NK cells, NK cells** can be divided into autologous NK cells** and allogeneic NK cells**. Autologous NK cells** are NK cells isolated from the patient themselves, expanded and activated in vitro, and then infused back into the patient. Allogeneic NK cells** are NK cells obtained from healthy donors or gene-edited immune cell banks, expanded and activated in vitro, and infused into patients.
3. Advantages and disadvantages of NK cells**.
1.Advantages: NK cells** are a non-specific immunity** that do not require tumor-specific antigens, can quickly recognize and kill tumor cells, and does not cause adverse reactions such as graft-versus-host disease. In addition, NK cells** can also enhance the body's immune function and improve the quality of life of patients.
2.Disadvantages: The disadvantage of NK cells** is that their efficacy is unstable, and the **effect varies greatly in different patients. In addition, in vitro expansion and activation techniques for NK cells are not yet fully mature and require further research and optimization.
Fourth, the application range of NK cells**.
At present, NK cells are mainly used for hematologic malignancies and solid tumors, such as acute myeloid leukemia, chronic myeloid leukemia, non-Hodgkin lymphoma, colorectal cancer, ovarian cancer, lung cancer, etc. In addition, NK cells can also be used for viral infectious diseases and autoimmune diseases, among others.
5. Progress in clinical research of NK cells**.
Currently, there are multiple clinical research projects on NK cells** underway around the world. Among them, some clinical trials have achieved certain results, showing the potential of NK cells in tumors and other diseases. For example, a clinical trial in acute myeloid leukemia showed that autologous NK cells** could significantly prolong survival and improve disease remission rates. In addition, some clinical trials have also tried to combine NK cells with other immunologic or chemotherapy drugs to improve** the effect.
6. Summary and outlook.
As an emerging immunology, NK cells have broad application prospects. Although the efficacy of NK cells** is still unstable, with the continuous advancement of technology and the in-depth understanding of the biological characteristics of NK cells, we believe that NK cells** will play an increasingly important role in the field of tumor immunity** in the future. In the future, we need to further optimize the isolation, expansion, and activation technologies of NK cells to increase their number and viability. At the same time, strengthen clinical research to explore its scope of application and optimal protocol in different diseases; It also focuses on ethical and regulatory issues to ensure the safety and legality of the technology. Through these efforts, we are expected to provide patients with a more effective, safe and personalized approach, and make a greater contribution to the cause of human health.