4'-Bromo-3-nitrobiphenyl (CAS: 32858-99-4), chemical formula C12H8BRNO2, is a white to light yellow crystalline powder. Its relative molecular mass is 27710 g mol, melting point 139-141 °C, boiling point 3765°c。At room temperature, 4'-Bromo-3-nitrobiphenyl is stable and not easily volatile.
Currently, 4'The synthesis of -bromo-3-nitrobiphenyls is mainly achieved by nitrosylation and bromination. First, the biphenyl substrate is nitrified to obtain 3-nitrobiphenyls, and then brominated to react 3-nitrobiphenyls with bromine to produce the target product. This synthetic route is simple and efficient, and is suitable for industrial production.
4'The preparation methods of -bromo-3-nitrobiphenyl mainly include traditional reactor synthesis and microchannel continuous synthesis. Traditional reactor synthesis includes two steps: nitrolation reaction and bromination reaction, with harsh reaction conditions and low yield. The microchannel continuous synthesis uses microreactors to achieve continuous production, improve yield, and reduce waste emissions.
4'-Bromo-3-nitrobiphenyl has a wide range of applications in the field of organic synthesis. It is an important intermediate compound that can be used in the preparation of chemicals such as pesticides, pharmaceuticals and dyes. In addition, 4'-Bromo-3-nitrobiphenyl can also be used as a reagent in the research field, as a catalyst or reagent for organic synthesis reactions.
The application of microchannel continuous technology in organic synthesis has attracted more and more attention. Through the microchannel reactor, the reaction conditions can be accurately controlled, the reaction efficiency and yield can be improved, and the waste generation can be reduced. In the future, with the continuous development and improvement of microchannel technology, it is expected to play a greater role in the field of organic synthesis and contribute to the sustainable development of the chemical industry.
4'-Bromo-3-nitrobiphenyl is an important intermediate compound in organic synthesis and has a wide range of application prospects. Through the optimization of synthetic routes and the development of microchannel continuity technology, its production efficiency can be improved, energy consumption and waste emissions can be reduced, and the chemical industry can be promoted to a greener and more sustainable direction. It is hoped that there will be more research and technological breakthroughs in the future to inject new vitality into the development of this field.