Article**: BTIT Club"** List of Quality Authors Currently, worldwide,There is only one drug under development for GADD45 - KES-0001, for multiple myeloma and diffuse large B-cell lymphoma, two serious blood disorders.
The original institution of the drug is located at Imperial College London, while Kesios Therapeutics Ltdis responsible for further research and development. 
The GADD45 family consists of three members: GADD45A, GADD45B, and GADD45G. These three members are like the guardians of the cell world, they are found in various tissues of the human body, silently regulating the occurrence of tumors, the balance of metabolism and the self-protection of cells. As scientists delve deeper into the GADD45 family, we learn more about these tiny but powerful proteins. Recently,The latest research results of X**ier Palomer et al. GADD45A: With or Without YouPublished in Med Research Reviews, the research team delved into a key member of the GADD45 familygadd45aThe article delves into its role in cancer, metabolic, neurodegenerative and cardiovascular diseases, and how it serves as a potential target for these diseases. 
Through a literature review, the existing research results are analyzed, and the function and regulatory mechanism of GADD45A in different disease backgrounds are analyzed, and it is like a "superhero" in the story, guarding our health.
The above figure illustrates the regulatory mechanism of GADD45A and its multifunctional role in biological processes such as cell survival, apoptosis, and cell cycle.
The nemesis of tumors
In the world of tumors, GADD45A is like a fearless warrior capable of identifying and stopping the "bad guys" who try to disrupt the order of cells. When cells are attacked by carcinogens, GADD45A rapidly activates intracellular defense mechanisms, helps cells repair damage, and even when necessary, it initiates the apoptosis program, by inducing apoptosis, reducing angiogenesis, etc., to promote abnormal cells to be cleaned up and maintain the body's health.
The complex mechanism of GADD45A exerts anti-tumor effects by regulating DNA repair, DNA demethylation, apoptosis, etc.
Regulator of metabolism
On the battlefield of metabolism, GADD45A transforms into a strategist, and it is finelyIt regulates the metabolic activity of fat cells。Imagine that while you're working up a sweat at the gym, GADD45A is also working hard in the "gym" inside your body, helping your body burn fat more efficiently, maintain a healthy weight, and help with weight management.
Guardian of the nerves
In the world of nerves, GADD45a is a gentle guardian. It plays a role in the brain, protecting neurons from damage and slowing down the progression of neurodegenerative diseases. For people like Alzheimer's disease, the presence of GADD45a slows the progression of the disease.
Cardiovascular and cerebrovascular diseases
The role of GADD45A in cardiovascular disease is multifaceted, it is both a key regulator of cellular stress and damage repair, and may also be involved in the pathological process of the heart. More research is still needed to further elucidate the specific mechanism and potential application of GADD45A in cardiovascular disease.
The story of the "superhero" of GADD45a plays out in our bodies every day. Professor X**ier Palomer and his team brought the "heroes" of the microcosm from behind the scenes to the front of the stage. Based on the above findings,GADD45A is likely to be a potential target for cancer, metabolic disease, cardiovascular disease, and neurodegenerative disease in the future. However, further research is needed to translate these findings into clinical practice to precisely regulate the function of GADD45a and explore its specific mechanism of action in specific diseases. References
1]palomer, x., salvador, j. m., griñán-ferré, c., barroso, e., pallàs, m., vázquez-carrera, m. (2024). gadd45a: with or without you. medical research reviews, 1–21. advance online publication. doi:10.1002/med.22015
2] New Drug Information Database. kes-0001
Written by: Xiao Yu.
Review: Shuxia.
Typesetting: Chu Han.