Building a network of medicinesWith years of experience in the biomedical industry, advanced instruments and equipment and drug R&D technology, Pharmalego is an e-commerce platform integrating R&D, production and sales of pharmaceutical intermediates, providing different types of molecular building blocks and pharmaceutical intermediates products, and is committed to providing customers with high-end customized synthesis services for pharmaceutical intermediates.
Pharmaceutical intermediatesIt refers to the key raw materials used in the production of drugs, which is a class of high-tech-intensive, high value-added, and purpose-specific chemical products, which are not only the basis of chemical synthesis drugs, but also widely used to modify the precursors obtained from natural extracts and biosynthesis. There are many varieties of pharmaceutical intermediates that can be purchased by customers and have high quality. Our products can not only be used for the synthesis of compounds in the drug discovery stage, scientific research in drug research and development, but also for new drug declaration, API and preparation production and other fields; At the same time, we provide small-scale customization of pharmaceutical intermediates products in the early stage and scale-up production services in the later stage to meet the product needs of customers from new drug research and development to the later clinical stage, and help accelerate the drug research and development speed of innovative pharmaceutical companies.
Molecular building blocksIt is usually used in the design and construction of small molecule active compounds, and is one of the important materials for drug research and development. In the field of ADC, PROTAC and oligonucleotide drug development, Zhuyao.com provides a series of molecular building block products for scientific research.
Building a network of medicinesIt is a leading manufacturer focusing on ADC (antibody drug conjugate) product customization and service, with R&D laboratories and high-activity drug production capabilities. We provide the molecular building blocks required for ADC drug development, and have rich chemical modification technology and capabilities, and the toxins and linkers in the library can meet the needs of customers from milligram to kilogram level R&D, realize the whole process service from drug R&D to preclinical CMC production, reduce R&D costs, and improve the speed and efficiency of drug R&D. We have built a rich and diverse ADC linker library (such as FMOC-GLY-GLY-PHE-OH, MC-VAL-ALA-PAB, FMOC-VAL-ALA-OH, 6-(2-(methylsulfonyl)pyrimidine-5-yl)hex-5-alkyne, etc.) to facilitate ADC drug development.
Protac blocksRefers to the linker unit used for the synthesis of protac-like molecules, the ubiquitin ligase E3 ligand unit. In terms of Protac drug R&D, Zhuyao.com has developed a series of highly active and selective target protein ligands and E3 ubiquitin ligase ligands. Protac linker libraries (e.g., pomalidomide, chlorpheniramine impurity F, 1-BOC-4-p-hydroxyphenylpiperidine, etc.) were designed and established. We have built a rich and diverse E3 Ligase ligand-linker library to speed up the development process of PROTAC-related products.
Oligonucleotide drugs, also known as small nucleic acid drugs, compared with traditional small molecule drugs and antibody drugs, has the characteristics of high efficiency, low drug toxicity and strong specificity. In oligonucleotide drug development, the modification of monomers and delivery systems is key. Zhuyao.com can provide customized and R&D services for monomers and delivery systems efficiently and quickly. We currently have more than 300 building blocks that can modify the ribose, base, and phosphate backbones of monomers, as well as the delivery systems, including galnac and LNP.
The active ingredient of the drug, that is, the API, is an important ingredient that plays a leading role in the drug. An intermediate is a material produced in the process steps of an API and must undergo further molecular changes or refinement to become an API. Due to the wide variety of medicines and the complex production process, there are many varieties and large demand for intermediates.
In general, Zhuyao.com is committed to providing a full range of services for drug development, including the research and development of ADC, RPOTAC and oligonucleotide drugs, to meet the needs of customers and improve the efficiency and speed of drug development.
The pharmaceutical intermediates of Zhuyao.com have a complete range of products and high product quality, providing high-purity benzene ring intermediates, heterocyclic intermediates, pyridine intermediates, deuterated intermediates, pyrimidine intermediates and other products to meet the needs of compound screening and drug synthesis in pharmaceutical R&D and scientific research; At the same time, we also provide large-scale packaging pharmaceutical intermediates products** and advanced pharmaceutical intermediates custom synthesis services, to provide customers with market-competitive and cost-effective products and solutions.
Our benzene ring intermediates product types include: biphenyls, naphthalene, phenols and nitrobenzenes, such as:
1) Biphenyl is a thermally stable compound, often used as a low-pressure and high-temperature heat transfer medium, which can be used alone or mixed with diphenyl ether. In addition, biphenyl is also used as a raw material for the manufacture of dyes, pharmaceuticals and other raw materials and antifungal agents for fruits.
2) Naphthalene can be used as a raw material for dye intermediates, insecticides, fungicides, antioxidants, surfactants, pharmaceuticals, etc., and solvents for determining molecular weight.
3) Phenol is widely used in the manufacture of phenolic resins, epoxy resins, nylon fibers, plasticizers, developers, preservatives, pesticides, fungicides, dyes, medicines, spices, etc.
4) Nitrobenzene is also an important chemical raw material, which can be used as an intermediate for a variety of pharmaceuticals and dyes, such as aniline, dinitrobenzene, benzidine, azobenzene, m-aminobenzene sulfonic acid, etc.
Heterocyclic compoundsIt is a commonly used pharmaceutical intermediate, including piperazine, pyridine, piperidine and furan.
1) Piperazine and its derivatives are an extremely important intermediate, such as piperazine hexahydrate, piperazine is a key intermediate in the production of drugs such as haloperic acid, pyridoxine, rifampicin and quinolone.
2) Pyridine and its derivatives are an important pharmaceutical intermediate with a wide range of applications, which are widely used in the synthesis of pharmaceutical products, and can be used as raw materials for the synthesis of steroid compounds, sulfonamides and their antihistamines. Amino derivatives of pyridine are mainly used in the production of general antihistamine-type compounds.
3) Piperidine is an organic synthetic raw material and intermediate, which can be used to manufacture painkillers, local fungicides and wetting agents.
4) Pyrazole is an intermediate in organic synthesis, containing halogen solvents, stabilizers and chelating agents for lubricating oils.
5) Furan can be used as a raw material for the manufacture of adiponitrile, butadiene and tetrahydrofuran.
In the first class of intermediates such as pyridines, deuterated drugs, pyrimidines, etc., we also have a large number of products for users to choose from.
Small molecule kinase inhibitors are currently a hot spot in the research and development of anti-tumor drugs, and Zhuyao.com provides products such as Pyrintegrin, BMS-986256, Paclitaxel Succinate, B-Rafin10, SRT2183 and PF-8380 to help pharmaceutical R&D workers in drug R&D.
The use of molecular building blocks and pharmaceutical intermediates can effectively support medical researchers in screening and evaluating a large number of potential compounds in the early stages of new drug development. This process not only helps to identify lead compounds that merit further investigation, but also optimizes those compounds to finalize drug candidates for clinical trials, significantly accelerating the development process for innovative pharmaceutical companies. Zhuyao.com focuses on providing high-quality products that meet the requirements of scientific research to meet the scientific exploration needs of pharmaceutical R&D personnel. We are equipped with state-of-the-art chemical synthesis and purification facilities, as well as a fully equipped analytical laboratory, to ensure that product quality is controlled at the source. All products are subject to strict quality inspection before being marketed, and provide customers with detailed test reports and accurate spectral information.