The second generation of IVF was developed on the first generation of IVF.
The first generation of IVF, as the medical profession says: in vitro fertilization-embryo transfer (IVF-ET). To put it simply, it is to take out a few eggs from the woman, take out ** from the man, and after processing, separate the sperm inside. The eggs and sperm are placed together in a petri dish and allowed to combine naturally, known as "conventional fertilization". "IVF" is just a colloquial term, embryos and babies are not cultured in IVF.
The general process of the first generation of IVF is as follows: the eggs and sperm are removed from the body, the sperm is washed to remove the sperm of poor quality, and the eggs are placed in a petri dish. As soon as the sperm and the egg meet, the stronger sperm will drill into the egg, that is, the egg will be fertilized and become a fertilized egg, and the fertilized egg will become an early embryo of several cells, and then transplanted into the uterus to continue to grow and develop until delivery.
Therefore, the first generation of IVF is suitable for such patients:
1. Egg transport disorders caused by various factors of the woman, such as bilateral fallopian tube obstruction, fallopian tube loss, severe pelvic adhesions and other fallopian tube dysfunction. The egg itself is healthy, but the fallopian tube is sick and there is no ability to transport the egg to the ampulla of the fallopian tube to meet the sperm, so the egg can only be artificially taken out of the ovary and meet the sperm outside the body.
2. Ovulation disorder: refractory ovulation disorder cannot be conceived after repeated routines**, such as repeated induction of ovulation or combined with intrauterine insemination**. In this case, there are eggs in the ovaries and cannot be released, and drugs are used to promote the release of the eggs, so the eggs can only be retrieved directly from the ovaries and the eggs can be fertilized in vitro.
3. There are also patients with endometriosis, who are still unable to get pregnant after drugs or surgery**, immune infertility and unexplained infertility, repeated intrauterine insemination** or other conventional** still not pregnant. First-generation IVF can be chosen.
But there are always some people's sperm is too weak, and thousands of sperm have been put in a culture vessel and co-existed with the egg, but there is still no capable sperm that can get into the egg, so they can only let the doctor help the sperm and send it into the egg, so that the egg becomes a fertilized egg, which is the second generation of IVF.
How do doctors help sperm move on to the egg?
A single sperm is injected directly into the cytoplasm of an egg under a microscope with a special microinjection needle to fertilize the egg. This is the second generation of IVF, called "intracytoplasmic sperm injection", the English abbreviation is: ICSI.
The process is the same as for the first generation: the fertilized eggs are cultured into early embryos and then placed back in the uterus to grow. It's that simple and easy to understand. So who has the sperm not the ability to burrow into the egg by itself and needs to use the second generation of IVF? For example: severe few, weak, teratospermia, these people have a small number of sperm and low motility, or although there are a lot of sperm, they are all crooked melons and cracked dates, poor quality, and have no ability to burrow into the egg by themselves. There are also some people whose sperm acrosomes are abnormal, which is equivalent to a problem with the drill bit of an electric drill, which cannot drill eggs, so they cannot enter.
Therefore, the second generation of IVF is not better than the first generation, the difference between them is for different patients, the right medicine, and there is no such thing as I am better than you!