F12 recombinant protein is a recombinant protein in plasma and is a member of the coagulation factor family. The protein encoded by the F12 gene, also known as the Hageman factor, is an important component of the blood coagulation system and has a variety of biological functions. The basic information and functional structure of the F12 recombinant protein are described in detail below.
Catalog No. PA1000-9468
Basic information on the F12 recombinant protein:
1.Gene and protein nomenclature: The protein encoded by the F12 gene is also known as the Hageman factor.
2.Molecular weight: The molecular weight of the F12 protein is about 80-85 kDa.
3.Tissue distribution: F12 protein is mainly found in the blood and is a protein closely related to the coagulation system.
4.Physiological function: F12 protein is involved in the activation cascade during blood coagulation and is one of the key factors for prothrombin activation.
Functional structure of F12 recombinant protein:
1.Activation mechanism: After being activated, F12 protein will come into contact with a high molecular weight activator to activate coagulation factor XI and form activation factor XIA.
2.Prothrombin activation: Activating factor xia is able to activate prothrombin (factor XII) under the right conditions, which triggers the production of thrombin and ultimately the process of blood clotting.
3.Lipid metabolism: In addition to its role in the coagulation process, F12 protein is also involved in the regulation of lipid metabolism. Studies have shown that mutations in the F12 gene may be associated with abnormal lipid metabolism.
4.Angiotensin production: The F12 protein can also regulate angiotensin production by activating the enzyme cateriopidase that produces angiotensin.
In general, F12 recombinant protein, as an important factor in the coagulation system, is involved in a variety of biological processes, including blood coagulation, lipid metabolism regulation, and angiotensin production. The study of F12 protein not only helps to deeply understand the mechanism of blood clotting process, but also provides new ideas and targets for related diseases. It is hoped that the function and biological significance of F12 protein can be further studied in the future.