Eight Nobel laureates and more than two dozen prominent scientists have recently come under public criticism** for associating their reputations with the campaigns of a company called Elysium Health, which sells nutritional supplements that claim to be anti-aging. Founded two years ago, Elysium Health offers a $50 monthly subscription to a nutritional supplement called Basis, which claims that its ingredients prolong the lives of lab rats. However, there is no conclusive evidence that BASIS has the same effect on humans. Since then, Elysium Health has been inviting 35 "scientific advisors" to join its team, including many Nobel laureates. Critics argue that these scientific pundits lend their academic influence to Elysium Health as if to assure the public that the placebo-like product can reverse the aging process. 
Eric Marcotulli, CEO and co-founder of Elysium Health, highlighted that many consumer brands in the "supplements" industry actually lack scientific evidence. He pointed out that consumers often struggle to find a team of professionals responsible for product development and quality assurance, as well as access to scientific research materials to support products and formulations, or even to contact company employees to answer questions. That's why Elysium Health has built an internal core team of leading scientists and an advisory board to explore new natural compounds, guide product development, and conduct clinical trials. A graduate of Harvard Business School, Eric Marcotulli was the youngest partner in Sequoia Capital's history, leading growth investments in the mobile technology space. While working in Silicon Valley, he realized that there was a massive lack of innovation in the consumer-facing healthcare market, in addition to wearables and mobile apps. With a deep interest in health management, he set out to start a company focused on developing health-promoting and anti-aging compounds found in nature, which is how Elysium Health came from. Leonard Guarente, Ph.D., co-founder and chief scientist at Elysium Health, is the Novartis Professor of Biology at the Massachusetts Institute of Technology and Paul F. at the MIT Center for the Study of Aging BiologyDirector of Glenn. He is known for his life-extension studies on model organisms such as budding yeast, Caenorhabditis elegans, and mice. Dr. Guarente's innovative aging research began with research on baker's yeast, a.k.a. saccharated yeast. After completing his Ph.D. at Harvard University, he opened his own research laboratory at the Massachusetts Institute of Technology. He noted that although research on aging at the time was largely focused on comparing the differences between older and younger animals through biology, few researchers attempted to unravel the causes of aging at the genetic and molecular levels.
Dr. Guarente chose to start his research with yeast because many of the key genes in yeast (or genes that closely resemble them) are also found in other organisms, including humans. These genes are evolutionarily "conserved", meaning that they play a universal role across different species. After 8 years of research with his postdoctoral team, Dr. Guarente identified an extremely important gene, SIR2. In 1999, his research team discovered that activating the Sir2 gene could prolong the life cycle of yeast. Soon after, they discovered that the activity of Sir2 requires a molecule called NAD+, which is present in all living cells. Research in the following years gradually revealed the significance of this discovery. Guarente's lab found that genes associated with SiR2 are present in all organisms, and these genes encode proteins called sirtuins. In humans, there are 7 known sirtuins, which are distributed in different areas of the cell and have slightly different functions, but they all require NAD+, which is very important for maintaining human health. By 2000, Guarente's lab published its findings confirming SIR2 as a NAD+-dependent protein deacetylase, a discovery that elucidated how SIR2 linked diet to physiology and suggested a possible mechanism for prolonging the life of some organisms through caloric restriction. These findings on the effects of sirtuins and NAD+ provide a solid scientific basis for Elysium Health's supplementation basis. Basis, the company's first product, aims to restore NAD+ levels and activate sirtuins, known as longevity genes. It is worth mentioning that Elysium Health has a scientific advisory board of more than 25 world-renowned experts and clinicians, including 8 Nobel laureates, whose research interests span neuroscience, genetics, complex chemical systems, and biochemistry.
Elysium Health's Index is a home biological age test that uses the latest generation of epigenetic technology to measure ten different dimensions of aging. Through the index test, users can learn about the biological age of different systems, the speed of body aging, and receive science-based lifestyle improvement recommendations, and users can also directly participate in Elysium Health's aging research projects. Using the company's high-precision epigenetic detection algorithm platform (APEX), Elysium Health is able to assess the user's biological age and system age by analyzing methylation sites on DNA. Measuring an individual's biological age is a challenge, especially in terms of accuracy and reliability. Repeated measurements of the same sample may produce up to 9 years of epigenetic age measurement bias. To develop an accurate and credible test method, Elysium Health collaborated with Dr. Morgan Levine, a leading figure in the field of epigenetics at Yale University. Index employs a unique machine learning solution that, according to the company, has been proven in Nature Aging to be the most accurate and reliable epigenetic age measurement method ever published. In contrast to biological age clocks, which typically detect hundreds of loci on the genome, Index reduces the "technical noise" that existed in previous aging clocks by detecting global methylation patterns. Index demonstrates greater accuracy than other published methods for measuring DNA methylation. While other clocks can produce a measurement deviation of 3 to 9 years in technical repeated tests, the index has a consistency deviation of only 0 to 1 in repeated testsbetween 5 years. In particular, the "systemic age" measured by the index covers the biological age of nine systems: brain, heart, metabolism, immunity, inflammation, kidney, liver, hormones, and blood. By tracking the aging of these systems over time, it is possible to gain a deeper understanding of each system's contribution to overall long-term health.
Basis: Developed by MIT professors to increase NAD+ levels by 40%.
Elysium Health has partnerships with multiple educational institutions, including Oxford University and Yale University, and its products are certified by NSF for sport and third-party testing for purity and quality. At present, the company is actively carrying out and completing 13 clinical trials on humans, aiming to understand the safety, efficacy and optimal dosage of its supplements. On September 21, 2021, Elysium Health successfully completed a Series C financing round with investment from The Venture Collective and Sprint VC, among others, and the specific amount of the financing has not been disclosed. According to Crunchbase**, Elysium Health has raised a total of $71.2 million to date, equivalent to about $5100 million RMB. Although Elysium Health has a high-profile scientific advisory board and a diverse product line, there are still some controversies and pitfalls behind the company. For example, some members of the Scientific Advisory Board have made it clear that their involvement is solely to provide product development and ingredient recommendations, and not to endorse Elysium Health's products. This has raised questions about whether companies are trying to use scientists' influence in academia to score points for themselves. In addition, experiments partially funded by Elysium Health have also been controversial. Will these experiments deviate from objective truth because they are driven by profit?And how can companies confirm the ineffectiveness of products that have already been marketed?Does the fact that the official website of the supplement focuses on the ingredients and the description of its effectiveness is more general, does this mean that it is not scientifically supported and credible?However, compared to other competitors, Elysium Health has a significant advantage in terms of the variety of supplements and the areas covered. Its product line covers a wide range of five key areas, including metabolism, anti-aging, brain function deterioration, immune aging and NAD+ levels, which is quite rare in its peers. Coupled with the financing scale of 500 million yuan and the progress of reaching the C round of financing, it is not a small amount in the industry. Therefore, in the midst of many controversies and supports, it is worth paying attention to whether Elysium Health, which has many advantages, can break through the encirclement. Signal: Targets metabolic aging by using the precursor NMN to increase NAD+ levels.
As people age, the speed and efficiency of metabolism in the body will gradually decrease, and this phenomenon will directly affect the functional performance of cells. This is mainly caused by two factors: on the one hand, it is because of the reduced levels of NAD+, which is essential for hundreds of metabolic activities and the production of cellular energy; On the other hand, the activity of NAD+-dependent mitochondrial enzymes, such as SIRT3, is also slowed down. Signal supplements are designed to address these issues and specifically target metabolic aging by protecting mitochondria to promote cellular energy production and use. Increasing the amount of NAD+ through NMN (nicotinamide mononucleotide), a precursor, supports energy production and activates SIRT3, a key mitochondrial enzyme, to protect mitochondria and promote the production of new mitochondria, helping cells adapt to the metabolic changes that occur with age. Signal supplements contain two main components, NMN and SIRT3 Activation Complex, which work together to help maintain a healthy state of metabolism. As an effective precursor of NAD+, NMN plays a central role in the creation of cellular energy and the execution of other key metabolic functions. The SIRT3 Activating Complex effectively supports healthy mitochondrial function by combining honokiol extracted from magnolia bark and viniferin extracted from grape vines. In addition, Signal has also shown significant results in maintaining blood sugar levels, improving exercise endurance, and reducing fatigue.
Mosaic: Targets aging and delivers visible results within 3 weeks.
As people age, the body's metabolism slows down and becomes less efficient, which has an impact on how quickly and efficiently the cells perform their functions. This phenomenon is mainly due to two aspects: on the one hand, the level of NAD+ in the body decreases, and NAD+ is the key to many metabolic processes and cellular energy production; On the other hand, some enzymes in the mitochondria, such as SIRT3, which rely on NAD+ to function, also slow down their activity. In response to these issues, SIGNAL supplements are designed to be effective responses. As a supplement specifically designed for metabolic aging, Signal is designed to promote cellular energy production and utilization by protecting the mitochondria. It uses NMN as a precursor to boost NAD+ levels, support energy production, and activate SIRT3, a key enzyme in mitochondria, to protect and promote the production of new mitochondria and help cells adapt to the metabolic changes that occur with age. Signal contains two components, nicotinamide mononucleotide (NMN) and SIRT3 activation complex, which work together to promote metabolic health. NMN, as a highly efficient NAD+ precursor, is essential for creating cellular energy and performing other key metabolic functions. The SIRT3 Activation Complex combines honokiol from Magnolia bark and grape pigment from grapevines to support healthy mitochondrial function. In addition, SIGNAL has played an important role in maintaining blood sugar levels, improving exercise endurance, and relieving fatigue. In response to the problem of aging, Elysium Health has launched a new systemic supplement, MOSAIC, which fights the phenomenon of aging from the innermost layer of cells. Mosaic was developed under the guidance of Dr. Richard Granstein, an authority in the field of disease, who has nearly 30 years of experience as head of the Department of Diseases at Weill Cornell Medical College and is one of the world's top scientific experts. According to Elysium Health's official website**, Mosaic has been proven in clinical trials to show significant results within 3 weeks of use. It is the first and only product on the market that combines a clinically proven phytonutrient carotenoid complex (PC complex) with hyaluronic acid to protect and maintain collagen levels, resist oxidation, and improve elasticity. Mosaic's formula is a blend of carotenoids and phytonutrients from tomato and rosemary extracts that work together to produce powerful antioxidant effects that protect, repair and improve**. Clinical trial results have shown that the PC complex can reduce wrinkles, improve skin texture and radiance, increase carotenoid levels by 31% after 16 weeks of oral administration, build an antioxidant library, and provide protection and balance against environmental challenges and oxidative stress. Clinical studies have also shown that supplementation with the PC complex in MOSAIC for 12 weeks can support a healthy inflammatory response and reduce redness after sun exposure. It is worth mentioning that MOSAIC uses oral hyaluronic acid in the form of oral hyaluronic acid, and its effect is incomparable to external use, which can further improve the water content of all layers of the body, improve the barrier function, and enhance the elasticity. Matter: Slows gray matter atrophy by an average of 86% for brain atrophy
As we age, the gray matter of the brain gradually shrinks, and even people in good health go through this process. When gray matter shrinks with normal aging, functions such as learning and memory, motor control, balance, and coordination are severely affected. Over the course of a person's lifetime, brain volume decreases by up to 20%.
To address this, Elysium Health has partnered with the University of Oxford to develop the supplement Matter. The supplement consists of a patented trivitamin complex, an advanced omega-3 formula, anthocyanins. Matter builds on the Vitacog study, a two-year clinical trial conducted at the University of Oxford in 168 older adults over the age of 70 with mild cognitive problems. The findings showed that the B vitamin complex in Matter slowed brain atrophy by 30% over a two-year period, and that gray matter atrophy was also slowed by an average of 86% in certain brain regions involved in visuospatial learning and spatial long-term memory.
Format: Targets immunosenescence and promotes intracellular circulation and renewal.
In addition, Elysium Health has developed supplements that target immunosenescence information. According to Elysium Health, it is the first and only product to fight immune senescence by pairing a daily immune supplement with an intermittent senescent cell clearance complex. The senescent cell scavenging complex developed by the company is designed to remove senescent cells that accumulate over time and lead to immunosenescence, protect cells from damage caused by free radicals and oxidative stress, induce autophagy, promote intracellular circulation and cell renewal.
This supplement formula innovatively combines two complementary daily and monthly systems, including a daily immune supplement and a twice-monthly senolytic complex. Among them, the daily immune supplement contains 100% vitamin C (90 mg), selenium (27 mcg) and zinc (5.).5 mg), these three high-potency micronutrients support both the innate and adaptive immune systems.
The Senolytic Complex promotes the clearance of senescent cells through quercetin and fisetin, two substances that have lytic activity in senescent cells. Panax notoginseng and chestnut rose (Rosa roxburghii) extracts further support normal senescent cell lysis activity and promote the clearance of senescent cells associated with strenuous exercise.
Elysium Health has partnered with prestigious educational institutions, including Oxford University and Yale University, and its products are certified by NSF for sports products and tested for quality and purity by an independent third party. Currently, Elysium Health is actively conducting and completing a total of 13 clinical trials in humans, aiming to deepen the safety, efficacy, and optimal dosage of its health supplements. On September 21, 2021, Elysium Health successfully completed its Series C financing round with the support of investors such as The Venture Collective and Sprint VC, although the specific amount of financing was not disclosed. According to Crunchbase, Elysium Health's total financing to date has reached US$71.2 million, equivalent to about 5 yuan100 million. However, there are also some controversies and potential issues that lie behind the many scientific advisors and diverse product lines that Elysium Health has. For example, some members of the Scientific Advisory Board have made it clear that they are not joining the committee to endorse Elysium Health's products, but simply to provide advice on product development and ingredients. This has raised questions about whether Elysium Health is using the academic prestige of scientific authorities to add credibility to its products. In addition, some of Elysium Health's self-funded research has also been questioned whether these studies will be affected by the company's interestsHow can a company prove that a product that is already on the market is invalid?Moreover, the introduction of supplements on the official website of Elysium Health mainly focuses on the ingredients, and the description of the product's effectiveness is more vague, and its scientific basis and reliability are sufficientHowever, if you look at it from another perspective, Elysium Health's product line involves five major areas, including metabolism, anti-aging, brain function decline, immune aging, and NAD+ levels, and its product coverage is particularly comprehensive compared to other companies in the same field, which usually only have 1-2 supplements. At the same time, the fact that the financing amount of 500 million yuan has reached and has entered the C round of financing should not be underestimated in this field. Therefore, among the voices of all sides, it remains to be seen whether the halo-filled Elysium Health will be able to break through the controversy and become a leader in the industry. 
Industry Brief: 2023 Medical Device Industry Challenges and Future Trends.
Research Report Highlights 2023 Digital Health Innovation of the Year***
The three departments issued the "Opinions on Further Strengthening the Construction of Health Culture in the New Era".
Insights into innovation in the healthcare industry
Pay attention to the ***ai intelligent medical network, and receive the forefront of the industry every day!