DSPE-PEG-RGD-FITC is a molecular complex with a specific structure and function, and its constituents include DSPE, PEG, RGD, and FITC. DSPE is distearoylphosphatidylethanolamine, which is a commonly used liposome synthesis material with good water solubility and biocompatibility. PEG is polyethylene glycol, which has good water solubility and biocompatibility, which can increase the hydrophilicity and stability of DSPE. RGD is the arginine-glycine-aspartic acid sequence, which is a common cell adhesion molecule that can bind to receptors on the surface of tumor cells to improve the targeting and efficacy of drugs. FITC is a fluorescein that enables the tracking and detection of complexes by fluorescence spectroscopy.
DSPE-PEG-RGD-FITC is based on a receptor that targets the surface of tumor cells, and specifically binds to the integrin receptor on the surface of tumor cells through RGD sequences to achieve targeted drug delivery. At the same time, the combination of DSPE and PEG can increase the stability of the drug, prolong the circulation time of the drug in the body, improve the efficacy of the drug and reduce the toxicity of the drug.
In practical application, it can be used in combination with other anti-tumor drugs to directly deliver drugs to the surface of tumor cells through targeted drug delivery, improve the efficacy of drugs and reduce toxicity.