Aunt Lin said to her son, "Go and see if this hospital has prescribed the wrong medicine." ”
For many years, Auntie Lin had been taking medication to control her diabetes as prescribed, but recently she felt persistent numbness in her legs, accompanied by a tingling sensation of pins and needles. At first, she thought it was caused by a herniated disc in her lower back, and tried to relieve it with a plaster, but the effect was very little, and the severe pain was more intense.
In order to find out the cause, Aunt Lin's son accompanied her to the hospital for a check-up. The doctor diagnosed peripheral neuropathy caused by diabetes and prescribed her medication.
When she got home, Aunt Lin checked the doctor's prescription and found that one of the boxes was methylcobalamin tablets. She remembered that the doctor had prescribed her this medicine before, but it was for high blood pressure. She was puzzled by the high blood sugar situation and suspected that the doctor had prescribed the wrong medicine, so she decided to send her son to the hospital for further information.
Under the doctor's explanation, Aunt Lin learned that methylcobalamin is an endogenous vitamin B12, which has a good effect on repairing nerves, and the doctor did not prescribe the wrong medicine.
Methylcobalamin is an endogenous vitamin B12 that is more easily absorbed and utilized by the body than vitamin B12 and has good nerve conductivity. When this active vitamin B12 enters the body, it can act quickly, promote the metabolism of folic acid and nucleic acids, and help improve the level of nerve excitability and transmitters, resulting in peripheral neuropathy.
Diabetic neuropathy is one of the common chronic complications in diabetic patients, involving the central nervous system and peripheral nerves, accounting for more than 60% of all diabetic neuropathies.
As an active vitamin B12, methylcobalamin quickly enters nerve cells, stimulates the synthesis of nucleic acids and proteins in neurons, and plays a role in repairing damaged nerve cells and improving nerve conduction velocity. This medication has significant benefits in relieving signs and symptoms in people with diabetic neuropathy without significant adverse effects.
Vitamin C and vitamin E are familiar vitamins, but few people know about vitamin B1. Found primarily in grains, meats, legumes, and dried fruits, it plays a number of important roles in the body, including protecting the heart, maintaining the normal functioning of the nervous system, preventing glucose metabolism disorders, and even benefiting from normal digestive function.
Vitamin B1 contains sulfur and amino groups in its structure, so it is called thiamine, also known clinically as antineuritamine, and is one of the first vitamins to be discovered.
As a water-soluble vitamin, vitamin B1 exerts physiological functions in the human body in the form of a coenzyme. It is a cofactor for key enzymes in glucose metabolism and also plays an important role in maintaining the balance of oxidative metabolism in the brain.
Vitamin B1 plays an important role in peripheral nerve damage. Once absorbed by the body, it is converted into the biologically active thiamine pyrophosphate, which becomes a component of decarboxylated coenzymes. It promotes the normal development and work of brain cells in the nervous system, provides energy to damaged nerve fibers, and reduces the inflammatory response of damaged nerve fibers.
After nerve damage, is it better to eat methylcobalamin or vitamin B1?
Although vitamin B1 and methylcobalamin differ in pharmacology, when thisCombination of two drugs, they exhibit a synergistic effect. Under the action of vitamin B1, it can more effectively promote the regeneration of nerve fibers by methylcobalamin, so as to repair nerve damage more quickly.
Although vitamin B1 and methylcobalamin are commonly used for peripheral nerve damage, it does not mean that they can be taken as many times as they like when certain symptoms occur. Overdose of these two drugs can cause damage to the body, so it is important to strictly follow the dosage and cycle for scientific and rational medication.
1.Daily intake dose
In daily life, it is important to consume the right amount of vitamin B1 and methylcobalamin every day. Vitamin B1 is a water-soluble vitamin that does not accumulate in the body, so it needs to be supplemented daily15mg。
For methylcobalamin intake, adequate vitamin B12 supplementation is usually sufficient and does not need to be taken alone. Intake 25 micrograms is enough, and the eggs, pork and various fruits in the food contain enough of these two substances.
However, in the case of peripheral nerve injury, the required dose is significantly increased. The usual dose is 10 mg three times a day. If you need to adjust the dose, you should do it on the advice of your doctor or pharmacist.
During the use of methylcobalamin **, the dose for adults is 05 mg three times a day, adjusted according to age and symptoms under the guidance of a doctor.
2.Duration of the cycle
*In peripheral nerve damage, methylcobalamin and vitamin B1 intake is much higher than daily needs, and long-term use may lead to a build-up of drugs that can trigger toxic reactions, especially methylcobalamin. Taking large amounts may cause them to collect around nerve fibers, which will not repair the nerve damage and may cause more damage.
During methylcobalamin**, the use of injections is usually determined based on the severity of symptoms. The frequency of intramuscular injections is usually 3 times a week for 14-28 days. After the course of treatment, methylcobalamin tablets and vitamin B1 are usually required for maintenance** for 3 months. For mild cases, methylcobalamin and vitamin B1 can be taken directly by mouth for 1-2 months.
3.People who take it with caution
Pregnant and lactating women: Methylcobalamin should be used with caution as lactating women should also be cautious as it has not been proven teratogenic, but it is possible to secrete it through breast milk.
People with allergies: there is a possibility of allergens, mild allergies, severe cases can cause allergic asthma and anaphylactic shock.
People exposed to mercury and its compounds: Methylcobalamin, which contains the metallic element cobalt, may be displaced with mercury, leading to heavy metal poisoning and multi-organ damage.
Patients with stone disease: Long-term use of vitamin B1 may aggravate the symptoms of stones, which is not conducive to ** and increases the difficulty of surgery.
Patients with gout: methylcobalamin may increase blood uric acid and induce gout attacks, so it should be taken with caution.
4.Precautions during use
Alcohol consumption is not recommended: Methylcobalamin contributes to neuronutrition, and long-term heavy alcohol consumption may lead to impaired neurological function.
Avoid smoking: Methylcobalamin and vitamin B1 should not be used at the same time as smoking for 30 minutes, because nicotine accelerates drug degradation and reduces drug effectiveness.
Do not drink caffeinated beverages: Caffeine stimulates the secretion of nerves and adrenaline, which will deplete vitamin B complex and affect the absorption of vitamin B1.