Article**labconco official website:
The labconco lyophilizer is a permanent equipment in the laboratory, and through the clever use of the coordination of refrigeration, vacuum and heating systems, it can magically transform the substance from solid to gaseous state, while retaining the original configuration and activity. However, it is not always easy to use the lyophilizer skillfully, and the following key points need to be kept in mind to ensure the efficient operation of the equipment and the excellent quality of the experimental samples. Here, we would like to share with you some experience and tips on how to use a laboratory lyophilizer to help you better appreciate the charm of this technology.
This article explains the use and precautions of the laboratory lyophilizer in detail, so as to help you learn to operate and maintain the equipment correctly, so as to improve the work efficiency and ensure the quality of the sample.
In the laboratory, we are often faced with the following problem: how to properly use the laboratory lyophilizerHow can I prevent instrument failures and ensure that my samples are not damaged?Let me answer these questions and share some practical skills.
Please pay attention to power and grounding: The laboratory lyophilizer must be connected to a separate power supply socket and ensure a good ground connection to ensure the safety and smooth operation of the equipment when you use it.
Stabilize room temperature: We recommend that you keep your lab lyophilizer running in the appropriate temperature range of 5-30 °C. Excessive temperature can cause damage to the compressor, so be sure to keep the unit within the proper temperature.
Start-up tips: After using the refrigeration equipment, please wait patiently for at least 3 minutes before starting the operation, so as to prolong the life of the compressor
Dear users, in order to ensure that the process runs as smoothly as possible, the following recommended process for using trays and lyophilized bottles is provided: If you need to use trays and external lyophilized bottles at the same time, please load the tray first, and then load the lyophilized bottles when the equipment reaches a condensing temperature of -50 or -80 and the air pressure is stable at 80 mtorr. This is done to prevent the hanging bottle items from melting when exposed to heat during the test. Thank you for your cooperation and understanding!
Dear readers, please note that samples that are not easy to freeze, such as organic solubils or high-concentration sugars, should be pre-frozen in a pre-freezing room below -80 for at least 24 hours, preferably more than 48 hours.
Please be careful with the plexiglass cabin: it should be gently placed on soft objects when removing to avoid damage to the plexiglass and possible vacuum leakage.
Take care to control the temperature and vacuum of the cold trap: set the temperature of the cold trap to the appropriate range (-55 to -40, or -85 to -80) according to the actual ambient temperatureAt the same time, maintain the vacuum level in a suitable range (5-100mtorr) to ensure the normal operation of the instrument.
Air Backfill Instructions: When implementing air backfill operations, please keep the pressure of the backfill air below 05kg to protect the equipment from damage.
Equipment placement and stability: In order to ensure the safety and stability of the freeze dryer, we strongly recommend that you place the machine at least 30 cm away from the wall, and use caster retainer to secure it after it is completely stable.
Please keep your distance: Do not place other heat dissipation equipment next to the laboratory lyophilizer, so as not to delay the circulation of cold air, affect the normal operation of the equipment or even damage the compressor.
Check the oil condition and quality in advance: Please check the oil distribution and quality in the vacuum pump before using it to ensure normal operation.
Dear users, we warmly remind you that before the evacuation operation, please be sure to pay attention to the following: First, plug the drain pipe;Secondly, the adapter system is turned off to prevent the vacuum pump from being affected. Thank you for your cooperation and support!
13.Please be sure to clean and maintain it regularly: In order to ensure the good operation of the equipment, please maintain the compressor and condenser fins regularly
Dear users, please use a professional laboratory lyophilizer to complete the lyophilization of the sample before the official start. Double-check that the device is connected to a dedicated power outlet and adjust the ambient temperature to the appropriate range as much as possible. Then, follow the correct steps to start, paying attention to the order in which the trays and vials are placed. To ensure a smooth operation, we recommend that you first cool the items to be frozen to the right temperature before elegantly disassembling the plexiglass compartment. During operation, it is necessary to pay attention to the temperature and vacuum changes of the cold trap at all times to prevent interference from heat sources around. After each operation, be sure to secure the equipment safely and check the oil quantity and quality of the vacuum pump in time. Happy operation!
When using the LabConco lyophilizer lyophilizer in the laboratory, the following points should be noted:
Make sure the power supply is grounded and the ambient temperature is appropriate
Operate the device in the correct boot sequence;
Pay attention to the order in which trays and lyophilized bottles are used;
The temperature and time should be controlled when the material is pre-frozen
Handle the plexiglass chamber with caution to avoid damage;
Control the temperature and vacuum of the cold trap within the normal range;
Pay attention to pressure control when air backfilling;
The device is placed stable and the casters are fixed;
Avoid other cooling devices nearby;
Clean the compressor and condenser regularly.
As a veteran manuscript writer, I also frequently use lyophilizer equipment in experimental environments. Based on the above strategies and points to note, I have successfully completed the lyophilization of many samples with high-quality results. Especially when it comes to the pre-freezing of materials and the details of the practical process, these tips play a decisive role in ensuring the integrity and stability of the sample.
These skills can be applied not only to solving problems in the lab, but also to everyday tasks. For example, in home cooking, these methods can effectively extend the shelf life of ingredients and ensure their quality. In industries such as pharmaceutical production and food processing, the use of these methods can also improve work efficiency and product quality.
After mastering these tips and tricks, I have noticed that the performance of my lab lyophilizer has improved dramatically. The lyophilization of the samples has been greatly improved, the operation process has been smoother, and the life of the equipment has been extended, which is similar to that expressed by many colleagues and partners. As a key piece of equipment in the process of scientific research, the correct use and maintenance of laboratory lyophilizer is very important, which affects the quality and work efficiency of experimental samples. The article reveals a series of practical tips, including the details to pay attention to in terms of power grounding, ambient temperature regulation, start-up steps, and material pre-freezing. By following these tips, you can be confident that you'll be proficient in navigating your lab lyophilizer and getting the results you want. Finally, everyone is welcome to share exclusive experiences and questions in the comment area and learn together.