Chronic rhinitis, chronic pharyngitis, chronic gastritis, chronic arthritis, ......Chronic inflammation is all too common. Many people think it's not a big deal when they hear the word "chronic", but the truth may completely turn your imagination upside down!
Chronic inflammation is a persistent, low-level inflammatory state that is associated with a variety of diseases
Cardiovascular disease: On the one hand, inflammation destroys the vascular endothelium and induces arteriosclerosisOn the other hand, it activates white blood cells, reacts with platelets, and forms blood clots, thereby increasing the risk of cardiovascular disease.
Diabetes: On the one hand, the inflammatory response affects the transport and absorption of insulin, causing insulin resistance and increasing the risk of diabetesOn the other hand, the secretion of a large number of inflammatory factors will damage pancreatic islet cells and accelerate the occurrence and development of diabetes.
Neurological diseases: Uncontrolled inflammation can directly poison the nervous system and damage neuronal cells.
Not only that, but studies have shown that chronic inflammation also plays a very important negative role in the occurrence, metastasis and ** process of tumors.
Chronic inflammation is tumorigenesis
*, the "fuse" of transfer
1. Chronic inflammation increases cancer risk.
On the one hand, chronic inflammation will make the body's tissues repeatedly in a state of damage-repair, and the cells will continue to proliferate and proliferate, the more times, the greater the probability of DNA replication errors, and the greater the possibility of cancer cells.
An article published in the internationally renowned journal "Trends Cancer" also pointed out that chronic inflammation can increase the probability of DNA mutation, directly mutagenesize or stimulate the proliferation of malignant cells, and drive tumor formation.
On the other hand, chronic inflammation can also reduce the function of the entire immune system, leading to an abnormal ability to recognize and remove tumor cells, further increasing the risk of cancer.
In recent years, studies have also shown that about 1 5 percent of cancer patients have long-term chronic inflammation stimuli, and 4 5 percent of cancer patients also have inflammatory cell infiltration in their cancer tissues [1]. The occurrence of stomach cancer, liver cancer, pancreatic cancer, etc., is related to chronic inflammation.
2. Chronic inflammation accelerates tumor metastasis,**
A study published in Scientific Reports reveals the detailed epigenetic mechanisms by which interleukin-1- (IL-1-) plays a key role in cancer metastasis.
IL-1- is a pro-inflammatory cytokine that, as the name suggests, has the effect of promoting inflammation. This study means that the question of "chronic inflammation helps cancer cells metastasize" has been confirmed by scientific research![2]
In addition to this, the researchers also found that in patients who already have cancer, inflammatory chemokines in the tumor microenvironment can "wake up" dormant cancer cells, promote growth, and cause aggressive metastases. [3]
Therefore, inflammation can be said to promote tumor metastasis, "tumor patients should pay attention to prevention and timely chronic inflammation while fighting cancer, so as to prevent inflammation from accelerating the occurrence and metastasis of tumors."
3 indicators were abnormal.
It may indicate chronic inflammation in the body.
Chronic inflammation is often subtle, but if there are abnormalities in the following items in your physical examination report, it may indicate that there is chronic inflammation in the body.
1. Elevated hypersensitive C-reactive protein.
Many people know that if the body has acute inflammation, the level of C-reactive protein in blood tests will increase dramatically. In other words, C-reactive protein in a blood test can be used to determine acute inflammation.
But did you know that there is also an indicator called "hypersensitive C-reactive protein", which is relatively sensitive and can be used for risk assessment of concomitant chronic inflammatory diseases, with a normal reference value of 0 3 mg L. Elevated levels may indicate chronic inflammation in the body and an increased risk of chronic inflammation-related diseases.
For example, as mentioned earlier, cardiovascular disease is associated with chronic inflammation, and studies have shown that high levels of hypersensitive C-reactive protein are associated with 3 times the risk of myocardial infarction.
2. Glycosylated hemoglobin.
Glycosylated hemoglobin is formed by the entry of glucose from the blood into red blood cells and attachment to hemoglobin, and its normal reference value is 4% 6%.
Elevated glycosylated hemoglobin indicates a high blood glucose level over the past 2 to 3 months. Long-term elevated blood glucose reacts with enzymes and other protein molecules to form the high-grade glycolytic end product of ages, which are highly inflammatory.
That is, elevated glycosylated hemoglobin may also indicate inflammation in the body.
3. The ratio of neutrophils to lymphocytes is unbalanced.
The ratio of neutrophils to lymphocytes (NLR) is a measure of stress and inflammation, and the optimal range of the ratio is 12~2.0。
When the body is dealing with chronic inflammation, the levels of lymphocytes drop and the levels of neutrophils rise, eventually leading to an imbalance.
If the number of neutrophils is more than twice that of lymphocytes, it may indicate chronic inflammation in the body.
"Anti-inflammatories" hidden in life
One more is beneficial.
In life, many bad habits can promote inflammation, such as: smoking and drinking, high-fat, high-salt and high-sugar diet, excessive intake of trans fatty acids, eating too much processed meat, and lack of sleep ......
On the contrary, there are many "anti-inflammatory drugs" hidden in life, and every time you do more, your body will benefit from one more, so learn it quickly
1. Put away this "anti-inflammatory recipe".
A scientific and reasonable diet can improve the chronic inflammatory state of the body.
The Cancer Nutrition Committee of the Chinese Anti-Cancer Association, the Community Nutrition and Health Management Branch of the Chinese Nutrition Society, and the Clinical Nutrition Branch of the Chinese Nutrition Society jointly issued the Expert Consensus on Anti-inflammatory Diet for Preventing Tumors, focusing on recommending the following anti-inflammatory diets.
Increase whole grain carbohydrates.
Whole grain carbohydrates are an important component of an anti-inflammatory diet, and their rich dietary fiber is both beneficial for maintaining stable blood sugar levels and helping to fight inflammationIt can also help improve intestinal flora and reduce inflammation levels.
Suggestion] Consume about 200 300g of whole grains per day, such as: wheat, barley, oats, rye, corn, sorghum, millet, etc.
Unsaturated fatty acids are the mainstay.
On the basis that the fat intake does not exceed 30% of the total energy intake, the proportion of unsaturated fatty acids should be increased as much as possible, and the intake of saturated fatty acids and trans fatty acids should be reduced, which is conducive to the formation of an anti-inflammatory internal environment of the body.
Suggestion] Nuts, fish, vegetable oil, etc. are rich in unsaturated fatty acids, it is recommended to control a small handful of nuts and edible oil at 25 30g a day, and eat aquatic products at least twice a week.
Eat enough fresh fruits and vegetables.
Fresh fruits and vegetables are rich in vitamins and minerals, and have good anti-inflammatory activity, and in an ideal anti-inflammatory diet, fresh fruits and vegetables should account for 2 3 of the total food weight.
Suggestion] Eat at least 300g of vegetables in your meals200 350g of fruits per day, but it is better to take low-sugar fruits such as watermelon, oranges, peaches, loquats, strawberries, cherries, etc., and limit the intake of high-sugar fruits such as coconut, hawthorn, banana, lychee.
Drink tea in moderation. The tea polyphenols in tea have anti-inflammatory biological activity, and tea can be drunk appropriately according to personal preference, but be careful not to be too strong.
A simple "anti-inflammatory recipe".
Some dietitians have shared some simple "anti-inflammatory recipes", which can be used as a reference for friends in need
Tri-color quinoa rice + instant chicken breast + boiled broccoli + small oranges.
Purple rice steamed bun + stir-fried shrimp with diced vegetables + cucumber + prune.
Instant chickpeas + lettuce and carrot fried chicken breast + winter dates.
Glutinous corn + cabbage stewed tofu.
Purple rice + stir-fried zucchini with tomatoes + braised chicken wings + kumquat.
Instant oatmeal + pan-fried mackerel + bell pepper + grapes.
2. Exercise often to train muscles.
When muscles contract, they are able to secrete some cytokines and actin with a small molecular weight, which enter the bloodstream and can reduce the inflammatory response throughout the body to a certain extent.
Usually you can build muscles through strength training such as elastic bands, kicking the wall with your legs, and lifting mineral water bottles.
3. Sleep better.
If you don't sleep well for a long time, your body will be in a state of chronic stress, which will promote the secretion of pro-inflammatory cytokines, making the whole body in a slightly inflammatory state.
It is recommended to go to bed before 23 o'clock every night to ensure 7-9 hours of sleep. If you have insomnia, dreams, easy to wake up, etc., you can eat some millet, flower beans, pumpkin seeds, bananas, sour jujube kernels, etc., which have the benefits of helping sleep. You can also try the following "sleep aid breathing method".
It's a big doctor, an official micro)