Human IgG, Mouse IgG, and Rabbit IgG are different species of immunoglobulin G (IgG), and they have some structural and functional differences.
Human, mouse, and rabbit IgG all belong to the immunoglobulin G (IgG) category and are one of the main antibodies produced by the mammalian immune system. Although they are similar in basic structure, i.e., consisting of two heavy chains and two light chains, forming a "Y" shaped molecular structure, there are some specific details between them.
1.Subclass differences: Humans haveFour IgG subclasses(IgG1, IgG2, IgG3, IgG4), whileMice have three IgG subclasses（igg1, igg2a, igg2b, igg3），Rabbits have only one type of IgG。There are differences between these subclasses mainly in the Fc moiety, affecting their ability to bind to Fc receptors and complement and their function in the immune response.
2.Amino acid sequences: Human, mouse, and rabbit IgG differ in amino acid sequences, which results in a diversity of antigen recognition parts (i.e., antigen binding sites). In addition, these differences also affect the stability and affinity of the antibody.
3.Glycation: in the IgG moleculeDegree and pattern of glycationThere will also be differences between different species. Glycation has important implications for antibody stability, solubility, and ability to bind to FC receptors and complement.
4.Affinity and specificity of antibodies: Because antibody production is the result of an immune response to a specific antigen, even human, mouse, and rabbit IgG against the same antigen can vary in affinity and specificity.
Therefore, while human, mouse, and rabbit IgG all fall into the IgG category, there are differences in subclasses, amino acid sequences, glycation, and antibody affinity and specificity that may affect their performance and efficacy in research and applications.