The academic bull was reported by a 113 page document!How many master s and doctoral students will b

Mondo Education Updated on 2024-01-29

This article**: Unspiraling

Recently, a doctoral student wailed:Due to the fraud of academic experts in the field, his graduation was affected and delayed!

Unexpectedly, after the pioneering research field of Alzheimer's disease published in the journal Nature last year, Science cracked down on counterfeiting and released the groundbreaking ** in the field of Alzheimer's disease research recently, and recently gave a hammer to the graduate students in this field:

The academic bull who has found a new direction of Alzheimer's disease that has nothing to do with amyloidIt was used as a 113-page documentto the National Institutes of Health (NIH).Report Academic Fraud!

This picture from July last year was given to friends who studied encephalopathy again:

After all, this one is from the University of Southern California (USC) in the United StatesA prominent neuroscientist suspected of serious academic misconductberisl** v.Zlokovic is an internationally recognized leader in Alzheimer's disease and stroke research, pioneering the study of pericytes, a type of cell that surrounds the capillaries of the brain and helps maintain the blood-brain barrier.

Four former lab workers who worked under him also confirmed the report to Science: in an anonymous interview with Science, they said that it was no accident that the whistleblower would find anomalous data. After all, Zlokovic often forces lab staff to "adjust" the data, even by changing lab laptops, to ensure that only the desired results are included in the experimental records.

Source: Screenshot of the University of Southern California Keck Medical Center.

If the content is true, Nagoya University last yearThrow away the laboratory ** more than 10,000 yuan Apple computer doctoral studentsThat's really nothing compared to him:

After all, it's also hard to get along with the computerZlokovic just changed the original data, and the doctoral student above threw the computer and was caught, and finally ** was retracted.

berisl** v.Zlokovic will be caught and reported this time to be related to the new stroke drug he developed. Yes, another scientist planted in the problem of new drug development.

Zlokovic and his team have developed a stroke drug called 3K3A-APC for brain cell death that can occur after a stroke. According to publicly released clinical trial data from ZZ Biotech, a biopharmaceutical company co-founded by Zlokovic, the 3A-APC drug** was effective in reducing minor, asymptomatic intracerebral hemorrhages.

However,According to the real data mined by the whistleblower, the data shows:

Six of the 66 stroke patients who received 3K3A-APC** died within the first week after **, compared to only 1 out of 44 stroke patients in the placebo group who died within one week after **. Although mortality stabilized after one month, at the end of the trial – i.e., 90 days after **, patients who received the drug developed more disability and dependence.

During the same period, patients who received 3K3A-APC** had significantly higher mortality and disability rates than those who received placebo. This means that the drug may have serious health risks and no significant efficacy advantage.

In a few months, the drug 3K3A-APC will be in phase 3 trials. The NIH (National Institutes of Health) will invest $30 million to support the clinical trial. For this reason, the NIH told Science that it takes the issue of research integrity very seriously, but declined to comment.

But just a few days ago, Science reported on the NIHFor nowStop 3K3A-APC to fund phase 3 trials andThe message that started the investigation

Pooja Khatri, a co-researcher at the StrokeNet National Coordination Center, admitted to Science that the NIH had hit the brakes. In addition, ZZ Biotech CEO Kent Pryor also confirmed to Science that clinical trials will be fully suspended during the NIH investigation, and he cannot comment on the trial timing until the NIH concludes the investigation.

What exactly does the 113-page whistleblower letter contain?Why did you let the NIH just hit the brakes?And why didn't the co-authors of the reported ** dare to check whether the image had been tampered with?

The following diagram shows where the whistleblower is listed35 falsified** and 2 falsified phase 2 clinical trial data:

The following are some of the **fake images selected and displayed by science:

Of these 35 fakes, 11 were co-authored by Griffin and ZlokovicAnd these 11 articles** have been published for more than 20 years。Griffin told Science that he adheres to the basic main conclusions of those ** and says he cannot guarantee that a particular image that has been flagged as potentially tampered has not been tampered with because he does not have access to the original for comparison.

The USC has conducted an internal review of Zlokovic regarding the content of the report.

According to statistics, zlokovic ** has fairly objective cited data:

If the results of the NIH and USC investigations confirm that Zlokovic has committed serious fraud, it will be for a significant number of master's and doctoral students who study encephalopathyIt would be sad news

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