In 2013, David Hinlekel, a professor at Harvard University in the United States, published a study in the authoritative biological journal "Cell", confirming that NAD+ supplementation can effectively delay the aging of the body through mouse experiments. Since then, the research on NAD and its precursors has attracted much attention, not only among major celebrities, but also in China
This discovery provides important hope for human anti-aging, marking that NAD+ may become the key to achieving human "immortality".。Several studies have shown that supplementing with NAD+ may help slow down the aging process.
Necessary raw materials for the synthesis of DNA repair enzymes
NAD+ is a coenzyme that is not only widely distributed in every cell of the human body, but is responsible for catalyzing more than 90% of the energy of life activities in the body; It also participates in the transformation of nutrients, affecting the rate of metabolism; It is also an essential raw material for the synthesis of DNA repair enzymes. It is able to activate our body's 7 major longevity enzyme families and is a miraculous anti-aging factor. As a person ages, the amount of NAD+ in the cells will gradually decrease. Timely increase of NAD+ levels in the body can achieve the effect of delaying aging and ensuring health
NAD+-dependent aging mechanisms
During aging, NAD+ levels decrease, leading to alterations in enzymes associated with NAD+ degradation and biosynthesis。This decline in NAD+ levels has been linked to the onset and progression of aging-related diseases, including atherosclerosis, arthritis, high blood pressure, cognitive decline, diabetes, and cancer. forTo restore NAD+ levels, people can consume NAD+ precursors through diet and use small molecule inhibitors to inhibit the activity of NAD+ degrading enzymes。These methods are considered to be potential strategies for restoring NAD+ levels.
Experimental effects of NAD+ supplementation
NAD+-boosting strategies have also been used to prolong lifespan for age-related diseases。The use of NAD+ supplements NR and NMN also effectively delayed the geriatric-like phenotype and prolonged lifespan in the associated group A xeroderma, ataxia telangiectasia and Cockayne syndrome models and in the nematode model of Werner syndrome, a progeria-like disease. In a mouse model of ataxia telangiectasia, NMN treatment significantly increased NAD+ levels and longevity. In a mouse model of muscular dystrophy, NR** also improves muscle stem cell function by regulating mitochondrial metabolism
In summary, NAD has an anti-aging effect. In addition, NAD can be used in health care products, cosmetics, diagnostic reagents and other fields。At the same time, further research by more scientists is needed to verify its safety and efficacy.
References: 1].