Anti-aging methods emerge in an endless stream, and NMN, as the most popular anti-aging substance in recent years, is well received by the market. In other words, why can NMN be an ideal choice for anti-aging?
What determines aging
Aging is a complex process that is influenced by a variety of factors. As we age, NAD+ levels in the body gradually decline. Reduced NAD+ levels lead to a weakening of cellular energy metabolism, a decrease in cellular function, and an acceleration of aging-related pathological processes.
Figure 1NAD+ in the human body declines with age.
Why choose NMN for anti-aging
Since the decline in the body's NAD+ level will lead to aging, isn't it okay to supplement NAD+ directly?This brings us to the particularity of NAD+. Because NAD+ itself is a highly active substance, it is unstable, and its molecular weight is too large to directly enter cells and cannot be directly absorbed by the body. However, it can be converted into NAD+ in the body by supplementing with NAD+ precursor substances. So which NAD+ precursor works better?
Highly effective NAD+ supplementation
NAD+ has a total of five precursors, including niacin (Na), tryptophan (TRP), nicotinamide (NAM), nicotinamide ribose (NR), and -nicotinamide mononucleotide (NMN). In the process of converting the other four precursors into NAD+, they either have their pathways blocked or they must first be converted into NMN, and then they can be converted from NMN to NAD+. And NMN is a direct precursor of NAD+, which may directly enter the cell with the help of a transporter, and will not be limited by rate-limiting enzymes, nor will it interfere with other physiological activities of the human body, nothing ***
The results of scientific research are relatively abundant
In 2013, Professor David Sinclair of Harvard Medical School found that mice 22 months after birth (equivalent to 60 years old) took NMN for a week, and their physical indicators returned to the state of 6 months (equivalent to 20 years old). The research results have been published in authoritative academic journals such as Science, Nature, and Cell. Since then, various studies have been conducted around the world on NMN and NAD+, and the results of the studies have confirmed Sinclair's above conclusions. At present, there are hundreds of studies** related to NMN and NAD+, providing an authoritative endorsement for the anti-aging efficacy of NMN.
Figure 3Decreased NAD levels induce a pseudohypoxic state.
The anti-aging effect is certified
A report published in 2023 from the well-known international journal "Elsevier" shows that NMN supplementation can increase NAD concentrations and can alleviate aging-related diseases, such as oxidative stress, DNA damage, neurodegenerative and inflammatory responses, etc. In addition, according to incomplete statistics, NMN also helps to prevent the three highs, diabetes, enhance immunity, prevent high blood pressure, alcohol metabolism, protect eyesight, improve sleep, etc.
Figure 4Safety and anti-aging effects of NMN in human clinical trials.
References: 1] Chini CCS, Cordeiro HS, Tran NLK, Chini EN nad metabolism: role in senescence regulation and aging. aging cell. 2023 jul 9:e13920.
2]gomes ap, price nl, ling aj, moslehi jj, montgomery mk, rajman l, white jp, teodoro js, wrann cd, hubbard bp, mercken em, palmeira cm, de cabo r, rolo ap, turner n, bell el, sinclair da. declining nad(+)induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. cell. 2013 dec 19;155(7):1624-38.
3]song q, zhou x, xu k, liu s, zhu x, yang j. the safety and antiaging effects of nicotinamide mononucleotide in human clinical trials: an update. adv nutr. 2023 nov;14(6):1416-1435.
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