Reticulocytes are the naïve stage of red blood cells, and their development and maturity need to undergo stem cell differentiation and proliferation in the bone marrow, gradually release them outside the medulla, and finally enter the blood circulation. Under normal conditions, the absolute reticulocyte count is relatively stable, but in some pathological cases, the absolute reticulocyte count decreases.
1. The reason for the decline in the absolute reticulocyte count.
1.Bone marrow hematopoietic dysfunction: Bone marrow hematopoiesis is an important part of erythropoiesis, and when bone marrow hematopoietic dysfunction occurs, it will lead to a decrease in erythropoiesis, resulting in a decrease in the absolute reticulocyte count. Common causes include aplastic anemia, myelodysplastic syndromes, etc.
2.Hemolytic anemia: hemolytic anemia is caused by the accelerated destruction of red blood cells, resulting in the inability of the bone marrow to replenish enough red blood cells in a timely manner, resulting in a decrease in the absolute reticulocyte count. Common causes include autoimmune hemolytic anemia, paroxysmal nocturnal hemoglobinuria, etc.
3.Drug effects: Certain drugs can affect the hematopoiesis of the bone marrow, resulting in a decrease in red blood cell production, which can lead to a decrease in the absolute reticulocyte count. Common drugs include chemotherapy drugs, immunosuppressants, etc.
4.Nutrient deficiencies: Deficiencies in nutrients such as vitamin B12 and folic acid can affect erythropoiesis, resulting in a decrease in the absolute reticulocyte count.
2. Absolute reticulocyte count decreases**.
1.Symptomatic**: For different **, take corresponding **measures. For example, for bone marrow hematopoietic dysfunction, hematopoietic stem cell transplantation, immunization, and other methods can be usedFor hemolytic anemia, drugs such as glucocorticoids and immunosuppressants may be used**.
2.Supplemental nutrition: For deficiencies in nutrients such as vitamin B12 and folic acid, it can be carried out through diet or supplementation of corresponding nutrients**.
3.Observation of the condition: For patients with mild disease, changes in the condition can be observed regularly, and potential ** can be detected and dealt with in time.
3. Prevention of decreased absolute reticulocyte count.
1.Pay attention to your diet: Maintain a balanced diet and consume enough nutrients, especially foods rich in vitamin B12, folic acid, etc.
2.Avoid contact with harmful substances: Avoid contact with harmful substances that may cause bone marrow hematopoietic dysfunction or hemolytic anemia, such as certain chemicals, radiation, etc.
3.Regular check-ups: For people with symptoms of anemia or a family history of hereditary history, regular blood tests should be done so that potential ** can be detected and treated in a timely manner.
In conclusion, a decrease in absolute reticulocyte count can be caused by a variety of causes, and understanding them and taking appropriate action is key. At the same time, maintaining good lifestyle habits and dietary structure, and avoiding exposure to harmful substances are also important measures to prevent the decline of absolute reticulocyte count. In daily life, if there are symptoms of anemia or abnormal blood tests, you should seek medical attention in time and make a professional diagnosis and**.