Chinese name: diphenylcyclooctyne-mercaptoyl.
Chinese alias: mercapto-modified dibenzocyclooctyne.
Product Name: dbco-sh
Synonyms: dbco-thiol
cas：2252493-06-2
Boiling Point: 7007±60.0 °c(predicted)
Density: 128±0.1 g/cm3(predicted)
Acidity coefficient: (pka) 978±0.10(predicted)
Storage conditions: -20
Solubility: water, dimethyl sulfoxide, dimethyl sulfoxide.
Uses: Only for scientific research, not for human body.
dbco-SH diphenylcyclooctyne-sulfhydryl is a bifunctional reagent commonly used in organic chemistry with high reactivity and selectivity. It is a very useful catalyst for cross-coupling reactions, which enables highly efficient thiol-olefin cross-coupling reactions under metal-free conditions.
The synthesis of DBCO-SH is usually achieved by reacting DBCO (diphenylcyclooctyne) with thiols. This reaction is a very efficient preparation method to generate bifunctional reagents with high activity and selectivity. During the reaction, the **cyclooctyne group of DBCO reacts with the sulfhydryl group of the thiol to form a stable conjugated addition product.
In addition to being used as a catalyst, DBCO-SH can also be used as a linker in the synthesis of various bioactive molecules and materials. For example, it can be used to synthesize biomolecules such as peptides, proteins, nucleic acids, etc., as well as to synthesize materials and devices with specific functions.