The research team of Westlake University has released 14 new research results!
What are the recent research results of Westlake University?
Take a look"Research Express"Part.
Cui Weicheng's team and collaborators from the School of Engineering.
Progress has been made in jellyfish propulsion research.
Distribution of vortex forces during the opening and closing phases of vortex clouds and shells.
On September 6, 2023, the team of Professor Cui Weicheng from the School of Engineering of Silake University and his collaborators published a paper entitled "PhysicsofFluids"."Propulsion performance and eddy dynamics of Jellyfish-LikePropulsion Withburst-and-Coast Strategy"Research Articles. The study is entitled:"Jellyfish-like propulsion with burst and coastal strategies"。The study sheds light on the effective use of jellyfish"Virtual wall"The hydrodynamic mechanism of the effect, through intelligent eddy current manipulation to achieve high thrust and high efficiency. The results of this study are of great significance for the development and design of jellyfish devices.
Wang Zhaobin Laboratory, Faculty of Science.
A new strategy for the synthesis of chiral amino alcohols.
Cross-coupling strategies for synthetic chiral-aminoalcohols.
On September 13, 2023, Wang Zhaobin's team from Westlake University published a paper entitled"cr-catalyzedasymmetriccrossaza-pinacolcouplingsforβ-amino alcohols synthesis "Research**. They developed a class of chromium-catalyzed asymmetric reductional coupling reactions of aldehydes and imines using the radical pole fork strategy, thereby obtaining a modular synthesis of high value-added chiral-amino alcohols. These results provide a new synthetic route for the synthesis of drug molecules containing amino alcohol backbones and chiral ligands.
Artificial Intelligence Main Venue: NERIP2023
A collection of the latest achievements in the field of artificial intelligence at Westlake University.
In September 2023, the acceptance results of neurips 2023 were released. A total of 12,343 valid papers were received at this meeting, and the acceptance rate was 261%。Nine papers** from Li Ziqing's Lab, Wang Donglin Lab and Zhang Yue Lab, Department of Artificial Intelligence, School of Engineering, Westlake University** were selected.
Neurips is currently one of the most prestigious artificial intelligence academic conferences in the world, and its full name is the Neural Information Processing Systems Conference. Neurips is usually held by the Neurips ** conference in December each year and is listed as an A-level conference by the China Computer Federation (CCF). The conference discussed many sub-fields such as deep Xi, computer vision, large-scale machine Xi, Xi theory, optimization, and sparse theory.
Wang Jianhui Group, School of Engineering.
About"Crystallization in situ"Recommendations for the strategy.
Extend the service life of high specific energy anode-free lithium batteries.
The study was published as a supplement in the journal NanoLetters.
Non-anode lithium batteries do not use anode materials in the production process, which improves the energy density while reducing the manufacturing cost of lithium batteries, and has broad application prospects. However, due to the copper current collector surface"Hate lithium"When lithium metal is deposited on the copper surface, obvious uneven nucleation, dendritic growth and a series of secondary reactions induced by it will occur, which seriously endangers the service life of non-anode lithium batteries. Previously, a large number of studies have attempted to improve the quality of lithium metal deposition by changing the surface of the copper current collector, but these methods have either caused a significant irreversible loss of capacity or are not stable enough to meet the needs of practical applications.
Wang Jianhui's research group proposed a"Implantation in situ"(ISI) strategy to eliminate the thermodynamic confinement effect of the copper substrate by nearly doubling the lifetime of the 437 Wh kg-1 Ah flexible anodized lithium battery by implanting it in situ in just 36 seconds after an assembled anode-less lithium battery. The research results were published in the article "Overcoming the Thermodynamic Limitations of Copper Substrates in Anodeless Lithium Batteries". On October 2, 2023, the results of the study were published with:"Overcoming the thermodynamic limitations of copper substrates in anode-free lithium pouch batteries"The title was introduced. freelithiumpouchcellsviainsituseedimplantation "It was published in the international journal nanoletters on October 2, 2023 and was selected as a secondary cover article.
He Lingjuan's team was unveiled in the School of Life Sciences.
Pregnancy causes the maternal liver to enlarge.
Cellular origin and mechanisms.
Cellular origin of hepatomegaly during pregnancy.
After mammals become pregnant, the mother's metabolic needs, hormone levels, blood volume and other aspects will change dramatically, and one of the very interesting phenomena is that the volume and weight of the maternal liver will increase to about twice the original after pregnancy. On October 3, 2023, Lingjuan He's team from the School of Life Sciences of Westlake University published an article entitled "Spatial- temporal proliferation of hepatocytes" in Cellstemcell. TemporalProliferationofHepatocytesduringPregnancyRevealedBygeneticlineagetracing" uses a variety of unique genetic methods to reveal the cellular origin and regulatory mechanism of maternal liver enlargement after pregnancy.
by the Academy of Sciences Cc.Submitted by LIU Labs.
A new strategy for the easy synthesis of 8-chain polysorbates.
The pre-organized double helix is connected by a silver or acetylene group to form a one-dimensional one"8 "Chain poly(Soxhlet) hydrocarbons.
On October 4, 2023, Zhichang Liu's research group from the School of Science at Silake University published a paper entitled "Atomic and Molecular Chemistry" (AngewandTechemie)."infinite twisted polycatenanes "Research Articles. Based on the pre-organization of the double helix, Liu's group successfully constructed an infinitely extended one-dimensional polycartene from covalently bonded metal ligands and organic matter. These results provide new ideas for the design and synthesis of advanced functional materials.
Reappearance of Wu Jie's laboratory in the Faculty of Science.
Copper oxide. Interfacial superconductivity in the heterostructure of high-temperature superconductors.
Schematic diagram of carrier motion on the LSCO(X) and LCO interfaces.
On October 25, 2023, Wu Jie's team from the School of Science of Westlake University, Xie Yanwu's team from the School of Physics of Zhejiang University, and Wu Yongjun's team from the School of Science of Westlake University published a paper entitled "NatureCommunication"."reentranceofinterfacesuperconductivityinahigh-tc cuprateheterostructure "Research Articles. This study reveals the long-standing problem of the possible formation of (super)conductive interface layers in some heterostructures, and provides guidance for the search for new compounds with interfacial superconductivity.
Zheng Kuisheng's team from the School of Life Sciences was unveiled.
At the beginning of life. Suffer from hunger.
May affect the intestinal flora in adulthood.
Increased risk of diabetes.
Starvation exposure, gut microbiota diversity, and the risk of type 2 diabetes.
a) Distribution of normalized gut microbiota diversity in each subgroup;
b) Statistical analysis of the relationship between exposure to hunger in early childhood and gut microbiota diversity and risk of developing type 2 diabetes.
On November 1, 2023, Zheng Ruisheng's team at Westlake University and its collaborators delivered a speech entitled ":"early-lifexposuretothegreatchinesefamineandgutmicrobiomedisruptionacrossadulthoodfortype2diabetes:threepopulation-basedcohortstudies "article. The study was created by a team"West Lake Intestinal Project"Based on a systematic analysis of data from 10,000 human gut microbiome from three independent cohorts of populations (aged 18 to 97 years) in 16 major provinces and cities in China, the impact of early hunger exposure on the adult gut microbiome was revealed for the first time, and it was found that gut bacteria associated with starvation exposure were strongly associated with an increased risk of developing type 2 diabetes. This discovery is:"Developmental origins of health and disease"Theory provides new perspectives for research.
Cai Shang's team from the School of Life Sciences.
Successfully built. Ex vivo mammary microbes mimic complex physiology and tumorigenesis.
A method for constructing a micro-organ of the breast.
On November 2, 2023, Cai Shang's team from Westlake University published a paper entitled "Nature Methods" in the journal Nature Methods"reconstructionofdynamicmammaryminiglandinvitrofornormalphysiologyandoncogenesis "article. In this article entitled"reconstruction of dynamic mammary minigland in vitro for normal physiology and oncogenesis "In this paper, we successfully constructed a dynamic culture system for mouse mammary glands, which can gradually induce mammary stem cells to form dendritic cavities with branched secondary structures, maintain similarity with normal mammary glands in terms of cell composition and transcriptional heterogeneity, simulate the physiological changes of mammary glands from puberty to pregnancy and lactation, and reproduce the physiological changes from embryonic to lactation. We can also simulate the physiological changes of the mammary gland during puberty, menstruation, pregnancy and lactation, reproduce the transition from embryonic to postnatal pluripotent stem cell fate to unipotent stem cells, and simulate the formation of breast epithelial cell tumors after the acquisition of proto-oncogenes. Compared with the previous mammary organoid culture system, the mammary microbes demonstrated in this study have better physiological structure, higher stability, longer culture time, and the potential to demonstrate more complex physiological and pathological processes, which is a powerful tool for studying mammary stem cell function, strain differentiation, microenvironment interactions, and the initial pathological process of tumorigenesis.
Ma Xianjue's team from the School of Life Sciences was unveiled.
The mechanism by which IRE1 determines cell fate during tumorigenesis.
The intercellular heterogeneity of IRE1 determines the fate of lost cells.
On November 3, 2023, Ma Xianjue's team at Westlake University published a paper entitled "CellReports":"differentialire1determineslosercellfateintumor-suppressivecellcompetition"Research**. The study concluded that the unfolded protein-responsive sensing enzyme IRE1 determines the fate of cells in tumor suppressor cell competition, and that the dependent mechanism of IRE1 varies at different levels.
Wu Mingxuan's team from the Faculty of Science.
A new approach to develop a highly efficient semi-synthetic histone H4.
Identification of readout protein H4K20Me3.
On November 15, 2023, Wu Mingxuan's team from the School of Science of Westlake University published a paper entitled "Cell Reports-Physical Science" (CellReportsPhysical Science)."decipheringhistoneh4lysineacetylationandmethylationviasortase-mediatedsemisynthesis "Research Articles. The research team has developed a method for the semi-synthesis of histone H4 by sorting enzyme-mediated transpeptidases, which can effectively introduce specific post-translational modifications into H4 and prepare the corresponding nucleosomes, providing a reliable research strategy for studying post-translational modifications of H4 in this field. Using this approach, the research team identified the deacetylation activity of sirtuin, an important class of deacetylases, on H4, and also identified the key modification of the H4K20Me3 reading protein PWWP4, providing new insights into the regulation of post-translational modifications of H4 in epigenetics.
Lu Qiyang's team from the School of Engineering was unveiled.
Effect of cross-phase boundaries on the mechanism of oxide-oxygen exchange reactions.
a) Schematic diagram of the in-situ electrochemical test setup;(b) High-resolution X-ray diffraction (HRXRD) spectroscopy of ProX films;(c) Different voltages (-1.) measured at 500°C and 1mbarpo2 operating conditions3~0.7V), (D) at extreme oxidation (0.).7v) and extreme reduction (-1.).Valanceband (VB) resonance optical emission spectra (Respes) measured at 3V) with photon energies between 920 EV and 940 EV (covering the PRM5 edge range). respes)
On November 16, 2023, Qiyang Lu's team from the School of Engineering at Silake University published an article entitled "Journal of the American Chemical Society"."differentiatingoxygenexchangereactionmechanismsacrossphaseboundaries "research results. differentiatingoxygenexchangereactionmechanismsacrossphaseboundaries"。In this work, Lu's team took praseodymium oxide (Prox), a commonly used oxygen electrode modified material in SOFC SOECS, as an example, and proposed for the first time to use an electrochemical method (chemical capacitance to obtain chemical capacitance through electrochemical AC impedance characterization) to correct the phase boundary, which is consistent with in-situ high-temperature X-ray diffraction (XRD) characterization. Subsequently, the oxygen exchange reaction mechanism of Prox in different phase structures was analyzed by an in-situ electrochemical measurement system. It was found that the catalytic reaction mechanisms were very different in Prox with different phase structures. At a fixed ionic defect concentration (fixed chemical oxygen potential), the PO2 in the oxygen-poor phase has a strong influence on the catalytic performance, i.e., it is the decisive factor in the overall catalytic reaction;In the oxygen-rich phase, the PO2 has little effect on the catalytic performance, suggesting that the ionic defect concentration is the decisive factor in the entire catalytic reaction in this phase.
Realized by the Shi Hang team of the Academy of Sciences.
Inert bond conversion of aromatic compounds.
At present, the chemical modification of transition metal-catalyzed aromatic compounds is mainly based on the classical catalytic method, that is, the metal catalyst is directly involved in the cleavage and formation of chemical bonds. However, due to the nature of the transition metal itself and the ligand, the nature of the target chemical bonds, and the surroundings"environment"and other factors, it is difficult for the above catalytic methods to selectively break the target chemical bond (i.e., the so-called inert chemical bond under limited conditions) in various situations.
Shi Hang's team from the School of Science of Westlake University realized the separation of inert carbon-carbon bonds and the transformation of carbon-silicon bonds through the arylation and activation of carbon-silicon bonds by transition metal ligands, respectively, providing a new catalytic strategy for the activation of inert bonds. The findings have been published in AngewandTechemie and Journal of the American Chemical Society, respectively.
Qiu Min's team from the School of Engineering.
Advances in micro-force probing using fiber optics.
Recently, the Qiu Min Laboratory of Westlake University, which takes micro and nano technology as the research direction"Light"Achieved the detection accuracy of the cattle level. On November 21, 2023, the international journal Advanced Materials** published the latest research results of the cooperation between Westlake University and the Hangzhou Advanced Research Institute of SUSTech, which realizes the low-force static detection at the leather cow level based on optical waveguides. Skin-level micro-force static detection based on optical waveguide has been realized.
The principle of a spring-loaded fiber optic micro-force sensor.
Source** Faculty of Life Sciences, Faculty of Science, Faculty of Engineering, Silek University.
Edited by Zhang Chi Proofread by Feng Yi