From ancient times to the present, the pace of human beings in the pursuit of longevity has never stopped.
Qin Shi Huang began to indulge in cultivating immortals at the age of 20, and sent his minister Xu Fu to Japan to find the elixir of immortalityIn the West, it is said that drinking the water filled with the "Holy Grail" can rejuvenate oneself, and King Arthur and other knights trekked through mountains and rivers to find the "spiritual spring".
But why do people get old?Scientists gave the answer back in the last century.
In 1965, the University of California cytologist Heflick put forward a theory: when the telomeres in the human body wear out, the cells will stop**, and this is how human beings go to aging and death.
Since the length of telomeres is already "set" at birth, how can we intervene in their length to achieve "longevity"?The latest research from the University of London gives a surprising answer: it can be achieved by "snatching" someone else's.
01.New study from the University of London: Telomere length is not enoughGrab someone else!
As one of the nine hallmarks of aging in the academic community, telomeres are present at the end of the chromosomes of cells, protecting their key parts like a sleeve, and will become shorter with each ** of cells in the body.
In other words, the length of telomeres determines our life expectancy to a certain extent.
California biologist Cw.It is proposed that if telomeres can be repaired or even lengthened, then almost everyone can break through the "limit" of 150 years old. Unfortunately, the existing "telomerase technology" that helps maintain telomere length has had little effect.
In 2022, a study published in the internationally renowned journal Nature Cell Biology attracted widespread attention from the academic community, and the research team from the University of London said that bypassing the traditional telomerase technology and "grabbing" other people's telomeres can lengthen their own.
The research team conducted experiments in mouse cells and human cells, and found that the survival of human immune cells can be extended by elongating telomeres.
To put it simply, they are "tearing down the east wall and making up the west wall" – antigen-presenting cells (APCs) tear down their telomeres and "don't" them to T cells. Surprisingly, this transfer effect is as much as 30 times that of traditional telomerase technology.
But in this way, APC's own telomere wear is irreversible, is there a way to achieve "mutual benefit and win-win"?
Based on this, the team came up with a bold idea - can we grab a few telomeres directly from others?After a series of studies, the answer is yes: the behavior of "telomere-grabbing" can even complete cross-species operations.
Extracellular vesicles containing telomeres extracted from human cells and mice are able to increase telomere length in human T cells. It's just that the effect of mice is slightly less. 02.Break through the traditional definition: how far is it to artificially "grab telomeres"?"Perhaps, in the future, we can slow down aging and even break through the limit of life by transferring telomeres. ”
Professor Alessio Lanna, head of the study, said.
Such an astonishing breakthrough has unsurprisingly raised questions from all walks of life - if the experiment moves towards practical application, who will lose their telomeres?
Under the "rampant" of extreme anti-aging measures such as stem cell ingestion and exchange transfusion in the rich circle, how can the rights and interests of ordinary people be protected?
In fact, scientific experiments are a long and very careful process, and it will take more time for the research results to reach human clinical and medical applications. In terms of maintaining telomeres and cell activity, scientists have discovered another kind of mature means, and Xiaoluquan "Celery" is one of the technologies that are popular in Japan.
Tracing the origin of this technology, the theoretical mechanism of Xiaoluquan comes from a study published in Nature in 2013 by Sinclair, a professor of genetics at Harvard, which confirmed that its core substance can reduce the degree of telomere wear and achieve intervention in the rate of telomere shortening, thereby slowing down human aging.
After clinical verification by top universities such as the University of Tokyo and the University of Washington, most elderly participants showed good aging inhibition effects after taking it. At the same time, the team of the School of Medicine of Sichuan University in China deconstructed the substance, and the research confirmed that it can correct DNA damage, improve cell quality, and most importantly, it can maintain telomere activity in the human body.
Referring to the business intelligence data, the positive feedback on the elimination of fatigue seems to confirm the research results, and there are even some remarks such as "more energetic in the morning" in the comment area.
Whether it is the research and development of various cutting-edge technologies or the booming market in China and Laos, it is certain that all mankind is committed to overcoming the problem of life.
03.Scientific research breaks through the boundaries, where is the way for ordinary people to survive?
In recent years, research in related fields is the so-called "a hundred flowers blooming", although the proposal of "telomere snatching" is still only in the experimental stage, but it has opened a new door for human beings.
It is not difficult to see that if this technology enters the application stage, it will be directly related to the barrier of human life, and it will undoubtedly bring great changes to human society. At that time, the average life expectancy of human beings, especially that of some of the top wealthy and cutting-edge biohackers, will reach an unattainable level.
At that time, what will the health and safety of ordinary people and even animals face?
Note: **Originated from the Internet.