What are the mechanisms of external hormone-containing ointments for psoriasis?Let's find out.
Topical corticosteroids can pass through ** and act directly inside the cells. It causes blood vessels to constrict and reduce the permeability of blood vessels, thereby reducing edema and cell exudation.
In addition, it can also stabilize lysosomal membranes by inhibiting the function of immune cells, hindering the response of phagocytic cells to antigens, and reducing inflammatory mediators produced and released by inflammatory cells. It can also reduce the proliferation and activity of immune cells, thereby alleviating the immune response and inflammation symptoms caused by immunocompetent cells and cytokines in **damage.
In addition, hormones can also inhibit the growth of germinal cells, thereby slowing down the growth rate of cells.
Common glucocorticoids are: methasone, butyrate, bran, pityrate, etc.
Possible adverse effects of topical glucocorticoids:
1.**Atrophy: Long-term use of hormone ointments may make **thinning, resulting in** easy to break, ecchymosis, and even depression under slight stimulation.
2.Atrophic marks: **After atrophy, due to the traction of activity, there may be wavy stripe-like depressions near the joints, which may initially have redness, swelling and mild bulges, and then gradually turn white and flat.
3.Burning, tingling, and itching: Localized burning, tingling, and itching sensations may occur after the use of hormonal creams, which may be due to increased sensitivity to external stimuli after thinning.
4.Telangiectasia: a common adverse reaction, usually co-occurring with atrophy.
5.Hirsutism: Long-term use of strong hormones or hormone creams may cause localized hair to increase, lengthen, and thicken.
6.Pigmentary changes: hypopigmentation or hyperpigmentation may occur.
7.Rashes such as facial papules, pus-scars, blackheads, telangiectasias, etc.: Long-term use of strong hormones or hormone creams on the face can cause these rashes and may develop a dependence on hormones.
8.Secondary infection: Long-term use of hormone ointments may lead to bacterial, fungal and other infections, such as folliculitis, ringworm, candida infection, etc.
9.Aggravation of psoriasis rash: long-term use of hormone ointment may make psoriasis rash dependent, and the rash may be aggravated, increased, and even transformed into an abscess-type rash after stopping the drug.
The potential risks of topical hormone-containing ointments are more and more well known to patients, and people may choose calcipotriol and the like, in fact, it is similar to the mechanism of hormone ointments, but the effect is slow, and the adverse reactions are less and the symptoms are less than those of hormones.